Evidence map›Paper›PMID 30709505›Full record

ReviewClinics in laboratory medicine2019

Signaling Molecules in Posttransplantation Cancer.

Murugabaskar Balan, Samik Chakraborty, Soumitro Pal

Abstract readReview
In one paragraph

Review in Clinics in laboratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Murugabaskar BalanDivision of Nephrology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Samik ChakrabortyDivision of Nephrology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Soumitro PalDivision of Nephrology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: soumitro.pal@childrens.harvard.edu.

Funding

Novel Role(s) of Nrf2 in the Growth of Post-Transplantation CancerR01CA193675 · NCI · BOSTON CHILDREN'S HOSPITAL · PI PAL, SOUMITRO · 2016 to 2020
$2.0M
Protective role of Honokiol in preventing c-Met-induced post-transplantation cancerR01CA222355 · NCI · BOSTON CHILDREN'S HOSPITAL · PI PAL, SOUMITRO · 2018 to 2022
$2.0M
NCI NIH HHS R01 CA193675NCI NIH HHS R01 CA222355
6 · The paper itself

Abstract

Immunosuppression is essential to prevent graft rejection. However, immunosuppression impairs the ability of the host immune system to control viral infection and decreases tumor immunosurveillance. Therefore, immunosuppression after organ transplantation is a major risk factor for posttransplantation cancer. Notably, recent reports suggest that immunosuppressive agents can activate tumorigenic pathways independent of the involvement of the host immune system. In this review, we focus on cell-intrinsic tumorigenic pathways directly activated by immunosuppressive agents and discuss the much-described infection- and immune-mediated mechanisms of cancer development in organ transplant recipients.

Indexed as

Signal TransductionCytokinesHumansImmunosuppression TherapyNeoplasmsOrgan TransplantationReceptors, ChemokineCytokinesReceptors, ChemokineCNIImmunosuppressionPosttransplantation cancerRisk factorSignaling mechanisms

Identifiers

PMID30709505
PMCPMC6368395

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.