ArticleArthritis research & therapy2019
Differences and similarities between IgG4-related disease with and without dacryoadenitis and sialoadenitis: clinical manifestations and treatment efficacy.
Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Clinical phenotypes and prognosis of IgG4-RD patients with allergy history: A retrospective cohort study.Clinical rheumatology · 2026Article
- From inflammatory initiation to fibrotic remodeling: mechanisms and precision therapeutic strategies in otorhinolaryngologic involvement of IgG4-related disease.Frontiers in medicine · 2026Review
- Implication of allergy and atopy in IgG4-related disease.The World Allergy Organization journal · 2023Review
- Serum IgG4 level during initial treatment as a predictor of relapse in IgG4-related disease.PloS one · 2023Article
- Different serum levels of IgG and complements and recurrence rates in IgG4-positive and negative lacrimal gland benign lymphoepithelial lesion.International journal of ophthalmology · 2023Article
- Lifetime Allergy Symptoms in IgG4-Related Disease: A Case-Control Study.Arthritis care & research · 2022Article
- Clinical and pathological predictors of relapse in IgG4-related disease.Arthritis research & therapy · 2022Article
- T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis.Autoimmune diseases · 2022Review
- IgG4-related aortitis/periaortitis and periarteritis: a distinct spectrum of IgG4-related disease.Arthritis research & therapy · 2020Article
- IgG4-related disease with multiple organs involvement was effectively controlled by glucocorticoids: a case report.AME case reports · 2020Article
- Different clinical patterns of IgG4-RD patients with and without eosinophilia.Scientific reports · 2019Article
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Authors and funding
18 authors.
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Abstract
backgroundThis study aimed to compare the differences and similarities in the clinical manifestations and treatment efficacy of IgG4-related disease (IgG4-RD) in patients with and without dacryoadenitis and sialoadenitis (DS).
methodsA total of 121 untreated IgG4-RD patients in Peking Union Medical College Hospital were enrolled in this study. The patients were divided into three groups: DS-predominant (group A), non-DS (group B), and DS with other internal organs affected (group C). The patients were followed up for at least 15 months. Baseline and follow-up data were collected. The disease activity was evaluated according to the IgG4-RD responder index.
resultsThe mean ± SD age at disease onset was 53.2 ± 14.1 years, and 71.9% of the patients were male. The prevalence of allergies was higher in groups A (21, 61.8%) and C (32, 69.6%) than group B (14, 34.1%). More patients with DS (17, 50.0%, and 17, 37.0%) had sinonasal lesions than those without DS (5, 12.2%). Moreover, an increased number of eosinophils were more common in patients with DS than in those without, as were increased serum IgG, IgG4, and IgE levels. More patients in group B and group C (28, 68.3%, and 31, 67.4%) received a combination therapy of corticosteroid and immunosuppressant. During the 15-month follow-up, 28 (23.1%) patients had disease relapse.
conclusionResults demonstrated that IgG4-RD patients with DS had distinctive clinical features compared with non-DS. Allergy and sinonasal involvement were more common in patients with DS. Patients with DS showed higher serum IgG4 levels than those without DS.
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