Evidence map›Paper›PMID 30709008›Full record

ReviewInternational journal of molecular sciences2019

Innovative Biomaterials for Bone Regrowth.

Maria Rosa Iaquinta, Elisa Mazzoni, Marco Manfrini, Antonio D'Agostino, Lorenzo Trevisiol, Riccardo Nocini, Leonardo Trombelli, Giovanni Barbanti-Brodano, Fernanda Martini, Mauro Tognon

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Revolutionizing bone healing: the role of 3D models.Cell regeneration (London, England) · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Rosa IaquintaDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy. mariarosa.iaquinta@unife.it.
Elisa MazzoniDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy. elisa.mazzoni@unife.it.
Marco ManfriniDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy. marco.manfrini@unife.it.
Antonio D'AgostinoDepartment of Surgery, University of Verona, 37129 Verona, Italy. antonio.dagostino@univr.it.
Lorenzo TrevisiolDepartment of Surgery, University of Verona, 37129 Verona, Italy. lorenzo.trevisiol@univr.it.
Riccardo NociniDepartment of Surgery, University of Verona, 37129 Verona, Italy. riccardo.nocini@gmail.com.
Leonardo TrombelliResearch Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara, 44121 Ferrara, Italy. leonardo.trombelli@unife.it.
Giovanni Barbanti-BrodanoSpine Surgery Unit, "Rizzoli" Orthopaedic Institute, 40136 Bologna, Italy. giovanni@barbantibrodano.com.
Fernanda MartiniDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy. fernanda.martini@unife.it.
Mauro TognonDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy. mauro.tognon@unife.it.ORCID 0000-0001-8269-7937

Funding

Regione Emilia Romagna NIPROGEN ProjectUniversità di Ferrara FAR ProjectsUniversità di Verona FRA projects
6 · The paper itself

Abstract

The regenerative medicine, a new discipline that merges biological sciences and the fundamental of engineering to develop biological substitutes, has greatly benefited from recent advances in the material engineering and the role of stem cells in tissue regeneration. Regenerative medicine strategies, involving the combination of biomaterials/scaffolds, cells, and bioactive agents, have been of great interest especially for the repair of damaged bone and bone regrowth. In the last few years, the life expectancy of our population has progressively increased. Aging has highlighted the need for intervention on human bone with biocompatible materials that show high performance for the regeneration of the bone, efficiently and in a short time. In this review, the different aspects of tissue engineering applied to bone engineering were taken into consideration. The first part of this review introduces the bone cellular biology/molecular genetics. Data on biomaterials, stem cells, and specific growth factors for the bone regrowth are reported in this review.

Indexed as

Bone RegenerationBiocompatible MaterialsHumansIntercellular Signaling Peptides and ProteinsRegenerative MedicineTissue EngineeringTissue ScaffoldsBiocompatible MaterialsIntercellular Signaling Peptides and Proteinsbiomaterialbonegrowth factorsregenerative medicinestem cells

Identifiers

PMID30709008
PMCPMC6387157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.