ArticleLife sciences2019
Immunophenotypic profile of leukocytes in hyperandrogenemic female rat an animal model of polycystic ovary syndrome.
Article in Life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Unraveling the mechanisms of PCOS: the interplay between gut microbiota and the immune system.Journal of ovarian research · 2026Review
- Natural killer cell dysregulation in polycystic ovary syndrome: immunometabolic and reproductive implication.Frontiers in immunology · 2026Review
- Elevated homocysteine levels predict impaired liver and renal function in women of reproductive age with polycystic ovary syndrome: aFrontiers in nutrition · 2025Article
- Mechanisms of traditional Chinese medicine regulating polycystic ovary syndrome through gut microbiota: a review.Frontiers in endocrinology · 2025Review
- The effect of adipose-derived mesenchymal stem cell transplantation on ovarian mitochondrial dysfunction in letrozole-induced polycystic ovary syndrome in rats: the role of PI3K-AKT signaling pathway.Journal of ovarian research · 2024Article
- The gut microbiota: emerging biomarkers and potential treatments for infertility-related diseases.Frontiers in cellular and infection microbiology · 2024Review
- Androgen-Induced Cardiovascular Risk in Polycystic Ovary Syndrome: The Role of T Lymphocytes.Life (Basel, Switzerland) · 2023Review
- Causal relationship between polycystic ovary syndrome and chronic kidney disease: A Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins.Frontiers in endocrinology · 2022Article
- Key Genes Associated With Non-Alcoholic Fatty Liver Disease and Polycystic Ovary Syndrome.Frontiers in molecular biosciences · 2022Article
- Aberrant miRNA-mRNA regulatory network in polycystic ovary syndrome is associated with markers of insulin sensitivity and inflammation.Annals of translational medicine · 2021Article
- Protective effects of berberine in a rat model of polycystic ovary syndrome mediated via the PI3K/AKT pathway.The journal of obstetrics and gynaecology research · 2021Article
- Effect of Wenshentiaojing Decoction on Hormone Level and Follicular Number in Patients with Menstrual Disorder of Polycystic Ovary Syndrome.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Effect of DHT-Induced Hyperandrogenism on the Pro-Inflammatory Cytokines in a Rat Model of Polycystic Ovary Morphology.Medicina (Kaunas, Lithuania) · 2020Article
- Immunophenotypic Profiles in Polycystic Ovary Syndrome.Mediators of inflammation · 2020Review
- Anti-Inflammatory and Antioxidant Effects ofJournal of evidence-based integrative medicineArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The immune etiology of polycystic ovary syndrome (PCOS) is an intriguing area. However, whether there is alteration in the leukocyte populations in different tissues remain ambiguous.
aimTo characterize the leukocyte populations of hyperandrogenemic female (HAF) rat tissues.
methodsFemale Sprague Dawley rats at 3 weeks of age were implanted subcutaneously with dihydrotestosterone (DHT) or placebo pellets. The rats were aged to 14-15 weeks and tissues were collected.
resultsPeripheral blood (PB) and renal CD4
conclusionResults from this study 1) provide the first evidence of significant alteration of T lymphocyte subsets and different leukocyte populations profile in a rat model of polycystic ovary syndrome, 2) demonstrate alteration of the immunological niche of blood, spleen, and kidney tissues in Hyperandrogenemia state in female rats, 3) imply potential immune system dysregulation in HAF rats which may suggest a link between excess androgen, chronic inflammation, and immune-mediated diseases in polycystic ovary syndrome patients.
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