Evidence map›Paper›PMID 30707926›Full record

ReviewThe Journal of steroid biochemistry and molecular biology2019

Steroid biomarkers in human adrenal disease.

Juilee Rege, Adina F Turcu, Tobias Else, Richard J Auchus, William E Rainey

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of steroid biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Surgery in practice and science · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Adrenal insufficiency.Nature reviews. Disease primers · 2021
    Review
  16. Review
  17. Article
  18. Update on adrenarche.Current opinion in pediatrics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Juilee RegeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States.
Adina F TurcuDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States.
Tobias ElseDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States.
Richard J AuchusDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, United States.
William E RaineyDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: WER@umich.edu.
University of Michigan · US

Funding

MECHANISMS LEADING TO ADRENAL ZONATIONR01DK043140 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI William E Rainey · 1999 to 2026
$7.2M
Activation of androgen biosynthesis and drug metabolism by cytochrome b5R01GM086596 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI RICHARD J. AUCHUS · 2009 to 2026
$4.8M
Molecular Mechanisms of AdrenarcheR01DK069950 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAINEY, WILLIAM E · 2005 to 2019
$4.4M
The contemporary endocrinology of congenital adrenal hyperplasiaK08DK109116 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2016 to 2020
$832k
NIDDK NIH HHS K08 DK109116NIDDK NIH HHS R01 DK043140NIDDK NIH HHS R01 DK069950NIGMS NIH HHS R01 GM086596
6 · The paper itself

Abstract

Adrenal steroidogenesis is a robust process, involving a series of enzymatic reactions that facilitate conversion of cholesterol into biologically active steroid hormones under the stimulation of angiotensin II, adrenocorticotropic hormone and other regulators. The biosynthesis of mineralocorticoids, glucocorticoids, and adrenal-derived androgens occur in separate adrenocortical zones as a result of the segregated expression of steroidogenic enzymes and cofactors. This mini review provides the principles of adrenal steroidogenesis, including the classic and under-appreciated 11-oxygenated androgen pathways. Several adrenal diseases result from dysregulated adrenal steroid synthesis. Herein, we review growing evidence that adrenal diseases exhibit characteristic modifications from normal adrenal steroid pathways that provide opportunities for the discovery of biomarker steroids that would improve diagnosis and monitoring of adrenal disorders.

Indexed as

Adrenal Gland DiseasesAdrenal GlandsBiomarkersBiosynthetic PathwaysHumansSteroidsBiomarkersSteroidsAdrenalAdrenal diseaseAndrogensBiomarkersSteroids

Identifiers

PMID30707926
PMCPMC6707065
OpenAlexW2912544865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.