Evidence map›Paper›PMID 30707763›Full record

ArticleCancer2019

Lasting effects of cancer and its treatment on employment and finances in adolescent and young adult cancer survivors.

Tyler G Ketterl, Karen L Syrjala, Jacqueline Casillas, Linda A Jacobs, Steven C Palmer, Mary S McCabe, Patricia A Ganz, Linda Overholser, Ann Partridge, Emily Jo Rajotte and 4 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 4 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The Impact of Thyroid Diseases on the Working Life of Patients: A Systematic Review.International journal of environmental research and public health · 2020
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Identity among adolescent and young adult cancer survivors: an exploratory qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Association of peripheral inflammatory cell counts with depression among cancer survivors: a cross-sectional study based on the NHANES dataset.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  15. Article
  16. GoFundMe®: Crowdfunding Among Young Adult Patients With Cancer.Clinical journal of oncology nursing · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Tyler G KetterlFred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0003-2359-473X
Karen L SyrjalaFred Hutchinson Cancer Research Center, Seattle, Washington.
Jacqueline CasillasJonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California.
Linda A JacobsAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Steven C PalmerAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Mary S McCabeMemorial Sloan-Kettering Cancer Center, New York, New York.
Patricia A GanzJonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California.
Linda OverholserUniversity of Colorado Cancer Center, Denver, Colorado.
Ann PartridgeDana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-4722-4824
Emily Jo RajotteFred Hutchinson Cancer Research Center, Seattle, Washington.
Abby R RosenbergDivision of Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, Washington.ORCID 0000-0002-7608-607X
Betsy RisendalUniversity of Colorado Cancer Center, Denver, Colorado.
Donald L RosensteinUniversity of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
Kevin Scott BakerFred Hutchinson Cancer Research Center, Seattle, Washington.
Seattle Children's Hospital · USFred Hutch Cancer Center · USUniversity of California, Los Angeles · USUniversity of Colorado Cancer Center · USUniversity of Pennsylvania · USDana-Farber Cancer Institute · USMemorial Sloan Kettering Cancer Center · USUniversity of North Carolina at Chapel Hill · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
Couple Communication in Cancer: A Multi-Method Examination - Renewal - 1R01CA201179 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Shelby Langer, LAURA S PORTER · 2016 to 2026
$7.2M
PEDIATRIC ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009351 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth R Lawlor, SOHEIL MESHINCHI · 1985 to 2026
$7.0M
Improving treatment of cardiovascular risk factors in childhood cancer survivorsR01CA204378 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHOW, ERIC JESSEN · 2017 to 2021
$3.7M
Integrating health informatics in a scalable stepped care self-management program for survivors after hematopoietic cell transplantationR01CA215134 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BAKER, KEVIN S, MAJHAIL, NAVNEET S. · 2017 to 2022
$3.6M
Improving Survivorship Care for Adolescents and Young Adults: a Mixed Methods Study of Alignment with the National Standards for Survivorship CareU01CA246659 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BAKER, KEVIN S · 2020 to 2025
$3.6M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA201179NCI NIH HHS R01 CA204378NCI NIH HHS R01 CA215134NCI NIH HHS T32 CA009351NCI NIH HHS U01 CA246659
6 · The paper itself

Abstract

backgroundThe impact of cancer and its treatment on employment and financial burden in adolescents/young adults (AYAs) is not fully known.

methodsEligibility for this cross-sectional study of AYA cancer survivors included the diagnosis of a malignancy between ages 18 and 39 years and survey completion within 1 to 5 years from diagnosis and ≥1 year after therapy completion. Participants were selected randomly from the tumor registries of 7 participating sites and completed an online patient-reported outcomes survey to assess employment and financial concerns. Treatment data were abstracted from medical records. Data were analyzed across diagnoses and by tumor site using logistic regression and Wald-based 95% confidence intervals adjusting for age (categorized), sex, insurance status, education (categorized), and treatment exposures.

resultsParticipants included 872 survivors (breast cancer, n = 241; thyroid cancer, n = 126; leukemia/lymphoma, n = 163; other malignancies, n = 342). Exposure to chemotherapy in breast cancer survivors was associated with an increase in self-reported mental impairment in work tasks (odds ratio [OR], 2.66) and taking unpaid time off (OR, 2.62); survivors of "other" malignancies reported an increase in mental impairment of work tasks (OR, 3.67) and borrowing >$10,000 (OR, 3.43). Radiation exposure was associated with an increase of mental impairment in work tasks (OR, 2.05) in breast cancer survivors, taking extended paid time off work in thyroid cancer survivors (OR, 5.05), and physical impairment in work tasks in survivors of "other" malignancies (OR, 3.11). Finally, in survivors of "other" malignancies, having undergone surgery was associated with an increase in physical (OR, 3.11) and mental impairment (OR, 2.31) of work tasks.

conclusionsCancer treatment has a significant impact on AYA survivors' physical and mental work capacity and time off from work.

Indexed as

AdolescentAdultCancer SurvivorsCost of IllnessCross-Sectional StudiesFemaleFinancing, PersonalHumansLogistic ModelsMaleNeoplasmsPatient Reported Outcome MeasuresUnemploymentYoung Adultadolescent/young adultcanceremploymentfinancessurvivorship

Identifiers

PMID30707763
PMCPMC6508988
OpenAlexW2911580731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.