ArticlePloS one2019
Impact of moderate to severe obstructive sleep apnea on the cognition in idiopathic pulmonary fibrosis.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Neurocognitive Impairment in Idiopathic Pulmonary Fibrosis: A Systematic Review of Current Evidence.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Prevalence and impact of comorbid obstructive sleep apnoea in diffuse parenchymal lung diseases.PloS one · 2021Pooled it
- Patients with idiopathic pulmonary fibrosis with and without obstructive sleep apnea: differences in clinical characteristics, clinical outcomes, and the effect of PAP treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Trial
- Neuropsychiatric disorders in pulmonary fibrosis: from brain network alterations to inflammatory mechanisms and therapeutic implications.Journal of neuroinflammation · 2026Review
- Cognitive impairment, depression, anxiety, and health-related quality of life in fibrotic ILD: a cross-sectional study.BMC pulmonary medicine · 2026Article
- Neurological Symptom Frequency, Cognitive Dysfunction, and Motor Impairment in Patients with Interstitial Lung Disease: A Cross-Sectional Analysis.Journal of clinical medicine · 2026Article
- Neurocognitive Dysfunction in Fibrosing Interstitial Lung Diseases: A Multidimensional Analysis of Pulmonary, Cognitive, and Clinical Correlates.Diagnostics (Basel, Switzerland) · 2025Article
- Neurocognitive and Neuropsychiatric Implications of Fibrosing Interstitial Lung Diseases.Biomedicines · 2024Review
- Review
- Article
- Article
- Treating sleep-disordered breathing of idiopathic pulmonary fibrosis patients with CPAP and nocturnal oxygen treatment. A pilot study : Sleep-disordered breathing treatment in IPF.Respiratory research · 2024Article
- Role of Sensory Nerves in Pulmonary Fibrosis.International journal of molecular sciences · 2024Review
- Elucidating shared biomarkers in gastroesophageal reflux disease and idiopathic pulmonary fibrosis: insights into novel therapeutic targets and the role of angelicae sinensis radix.Frontiers in pharmacology · 2024Article
- The interplay of physical and cognitive function in rehabilitation of interstitial lung disease patients: a narrative review.Journal of thoracic disease · 2023Review
- Prognostic Significance of Obstructive Sleep Apnea in a Population of Subjects with Interstitial Lung Diseases.Pulmonary therapy · 2023Article
- Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis.Scientific reports · 2023Article
- Overlaps between obstructive sleep apnoea and other respiratory diseases, including COPD, asthma and interstitial lung disease.Breathe (Sheffield, England) · 2022Review
- The Association between Idiopathic Pulmonary Fibrosis and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Cell-Selective Altered Cargo Properties of Extracellular Vesicles Following In Vitro Exposures to Intermittent Hypoxia.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIdiopathic pulmonary fibrosis (IPF) is a relentlessly progressive lung disease with a fatal prognosis to whose rapid evolution multiple comorbidities may contribute, one of the most common being obstructive sleep apnea (OSA). There are several potential factors and conditions for the emergence of a cognitive deficit in relation to IPF or associated morbidities.
objectivesThe goals of this study were to assess cognition in patients with IPF in stable phase and to identify clinical cognition modifiers.
methodsIn a cross-sectional study, 23 patients with IPF were evaluated using Montreal Cognitive Assessment (MoCA), an instrument for detecting mild cognitive impairments and were screened for OSA through overnight cardiorespiratory polygraphy and for anxiety and depression with three specific scale (Generalized Anxiety Disorder 7-item scale: GAD-7; the Patient Health Questionnaire: PHQ-9; Hospital Anxiety and Depression Scale: HADS).
resultsMoCA score was lower in patients with IPF when compared to controls subjects (24 [21,26] vs. 27 [26,28], p = 0.003) but not as significantly as in COPD patients (21 [18.8,23.3], p<0.0001). OSA was diagnosed in 19 (82.6%) IPF patients, 12 patients showed the presence of moderate-severe forms (63.15%). IPF patients with cognitive impairment (MoCA<23) exhibit a higher severity of OSA (apneea hypopnea index-AHI: 33.0±19.1 vs. 12.44±8.2, p = 0.018), and a higher Epworth score (7.1±3.3 vs. 4.3±1.8, p = 0.013). Anxiety and depression scores were not correlated with MoCA results.
conclusionsImpaired cognition in patients with IPF is mild and affect the areas of visuospatial abilities, language and working memory. OSA could be a possible predictor of IPF cognition deficit. Given the high prevalence of multiple types of sleep disorders in IPF patients, these should be investigated at least by cardiorespiratory polygraphy.
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