ArticlePloS one2019
Trabecular bone score in active or former smokers with and without COPD.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mild Hyponatremia Is Not Associated With Degradation of Trabecular Bone Microarchitecture Despite Bone Mass Loss.The Journal of clinical endocrinology and metabolism · 2025Article
- Mechanisms of osteoporosis associated with chronic obstructive pulmonary disease.Journal of bone and mineral metabolism · 2024Review
- Bone Mineral Density and Trabecular Bone Score Changes throughout Menopause in Women with HIV.Viruses · 2023Observational
- Article
- Association of short sleep duration and trabecular bone score.Scientific reports · 2021Article
- Factors associated with TBS worse than BMD in non-osteoporotic elderly population: Bushehr elderly health program.BMC geriatrics · 2021Article
- The association of tobacco smoking and bone health in the elderly population of Iran: results from Bushehr elderly health (BEH) program.Journal of diabetes and metabolic disorders · 2020Article
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Authors and funding
14 authors.
Funding
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Abstract
backgroundSmoking is a recognized risk factor for osteoporosis. Trabecular bone score (TBS) is a novel texture parameter to evaluate bone microarchitecture. TBS and their main determinants are unknown in active and former smokers.
objectiveTo assess TBS in a population of active or former smokers with and without Chronic Obstructive Pulmonary Disease (COPD) and to determine its predictive factors.
methodsActive and former smokers from a pulmonary clinic were invited to participate. Clinical features were recorded and bone turnover markers (BTMs) measured. Lung function, low dose chest Computed Tomography scans (LDCT), dual energy absorptiometry (DXA) scans were performed and TBS measured. Logistic regression analysis explored the relationship between measured parameters and TBS.
resultsOne hundred and forty five patients were included in the analysis, 97 (67.8%) with COPD. TBS was lower in COPD patients (median 1.323; IQR: 0.13 vs 1.48; IQR: 0.16, p = 0.003). Regression analysis showed that a higher body mass index (BMI), younger age, less number of exacerbations and a higher forced expiratory volume-one second (FEV1%) was associated with better TBS (β = 0.005, 95% CI:0.000-0.011, p = 0.032; β = -0.003, 95% CI:-0.007(-)-0.000, p = 0.008; β = -0.019, 95% CI:-0.034(-)-0.004, p = 0.015; β = 0.001, 95% CI:0.000-0.002, p = 0.012 respectively). The same factors with similar results were found in COPD patients.
conclusionsA significant proportion of active and former smokers with and without COPD have an affected TBS. BMI, age, number of exacerbations and the degree of airway obstruction predicts TBS values in smokers with and without COPD. This important information should be considered when evaluating smokers at risk of osteoporosis.
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