ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Modulating cardiac conduction during metabolic ischemia with perfusate sodium and calcium in guinea pig hearts.
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Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- The influence of intercalated disk nanostructure on local ionic currents and cardiac conduction.Biophysical journal · 2026Article
- Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3.bioRxiv : the preprint server for biology · 2025Article
- Analytical Insights into Ephaptic Coupling and Its Effect on Conduction Velocity.Journal of mathematical biology · 2025Article
- Quadruple parametric optical mapping to measure cardiac metabolism-excitation-contraction coupling.Communications biology · 2025Article
- Role of ionic electrodiffusion and ephaptic coupling in cardiac dynamics.Biophysical journal · 2025Article
- Sequence-Dependent Repolarization Is Modulated by Endogenous Action Potential Duration Gradients Rather Than Electrical Coupling in Ventricular Myocardium.Journal of the American Heart Association · 2025Article
- New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?Heart rhythm · 2025Review
- The role of ephaptic coupling and gap junctional coupling in modulating the initiation and dynamics of reentrant arrhythmias.PloS one · 2025Article
- Acute Adenoviral Infection Elicits an Arrhythmogenic Substrate Prior to Myocarditis.Circulation research · 2024Article
- Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function.American journal of physiology. Heart and circulatory physiology · 2024Article
- Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction.Circulation research · 2023Article
- The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes.Physiological reviews · 2023Review
- Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022Review
- Article
- Predictive Capability of Metabolic Panels for Postoperative Atrial Fibrillation in Cardiac Surgery Patients.The Journal of surgical research · 2022Article
- Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique.American journal of physiology. Heart and circulatory physiology · 2022Review
- Epicardial adipose tissue as a mediator of cardiac arrhythmias.American journal of physiology. Heart and circulatory physiology · 2022Review
- Ephaptic Coupling Is a Mechanism of Conduction Reserve During Reduced Gap Junction Coupling.Frontiers in physiology · 2022Article
- Mechanisms of arrhythmia termination during acute myocardial ischemia: Role of ephaptic coupling and complex geometry of border zone.PloS one · 2022Article
- Stop the beat to see the rhythm: excitation-contraction uncoupling in cardiac research.American journal of physiology. Heart and circulatory physiology · 2021Review
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Authors and funding
12 authors at 3 institutions in 2 countries.
Sharon A GeorgeDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University , Blacksburg, Virginia.
Gregory HoekerCenter for Heart and Reparative Medicine Research, Virginia Tech Carilion Research Institute , Roanoke, Virginia.
Patrick J CalhounCenter for Heart and Reparative Medicine Research, Virginia Tech Carilion Research Institute , Roanoke, Virginia.
Michael EntzDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University , Blacksburg, Virginia.
Tristan B RaischCenter for Heart and Reparative Medicine Research, Virginia Tech Carilion Research Institute , Roanoke, Virginia.
D Ryan KingCenter for Heart and Reparative Medicine Research, Virginia Tech Carilion Research Institute , Roanoke, Virginia.
Momina KhanDepartment of Human Food Nutrition and Exercise, Virginia Polytechnic Institute and State University , Blacksburg, Virginia.
Chandra BakerCenter for Heart and Reparative Medicine Research, Virginia Tech Carilion Research Institute , Roanoke, Virginia.
Robert G GourdieDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University , Blacksburg, Virginia.
James W SmythCenter for Heart and Reparative Medicine Research, Virginia Tech Carilion Research Institute , Roanoke, Virginia.
Morten S NielsenDepartment of Biomedical Sciences, University of Copenhagen , Copenhagen , Denmark.
Steven PoelzingDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University , Blacksburg, Virginia.
Virginia Tech · USCarilion Roanoke Memorial Hospital · USUniversity of Copenhagen · DK
Funding
PATTERNING OF GAP JUNCTION COUPLING IN DEVELOPING HEARTR01HL056728 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G · 1997 to 2021
$5.6MRole of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9MSignaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6MTranslation initiation in cardiac intercellular communication and stress-induced remodelingR01HL132236 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SMYTH, JAMES WILLIAM · 2017 to 2021
$2.0MThe Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8MExtracellular Spaces and Cardiac ConductionF31HL140873 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI RAISCH, TRISTAN · 2018 to 2019
$46kNHLBI NIH HHS F31 HL140873NHLBI NIH HHS R01 HL056728NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL132236NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01 HL141855
Abstract
We previously demonstrated that altering extracellular sodium (Na
Indexed as
Action PotentialsAnimalsArrhythmias, CardiacCalciumConnexin 43Gap JunctionsGuinea PigsHeart Conduction SystemHeart VentriclesIn Vitro TechniquesMaleMyocardial IschemiaOsmolar ConcentrationSodiumCalciumConnexin 43Sodiumarrhythmiacalciumconductionischemiasodium
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Textmetadata
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.