ArticleObesity (Silver Spring, Md.)2019
Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent.
Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- A Systematic Review and Meta-analysis of Sex Differences in Subcutaneous and Visceral Abdominal Fat in Children.Nutrition reviews · 2026Pooled it
- Sex-specific longitudinal associations between repeatedly measured movement behaviours and adiposity measures in school-aged children: a compositional data analysis approach.International journal of obesity (2005) · 2026Article
- Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood.International journal of epidemiology · 2023Article
- The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.The Journal of clinical endocrinology and metabolism · 2022Article
- CAFT: a deep learning-based comprehensive abdominal fat analysis tool for large cohort studies.Magma (New York, N.Y.) · 2022Article
- Estimating trunk fat in children according to sex using basic somatic readings: an opportunity for improving evaluation among girls.BMC pediatrics · 2021Article
- Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children.The Journal of clinical endocrinology and metabolism · 2021Article
- Automated Segmentation of Visceral, Deep Subcutaneous, and Superficial Subcutaneous Adipose Tissue Volumes in MRI of Neonates and Young Children.Radiology. Artificial intelligence · 2021Article
- The longitudinal association between early-life screen viewing and abdominal adiposity-findings from a multiethnic birth cohort study.International journal of obesity (2005) · 2021Article
- Trajectories of Systolic Blood Pressure in Children: Risk Factors and Cardiometabolic Correlates.The Journal of pediatrics · 2021Article
- Mismatch between poor fetal growth and rapid postnatal weight gain in the first 2 years of life is associated with higher blood pressure and insulin resistance without increased adiposity in childhood: the GUSTO cohort study.International journal of epidemiology · 2020Article
- Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study.The American journal of clinical nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 4 countries.
Funding
Abstract
objectiveThe aim of this study was to investigate the independent associations between age-specific annual weight gain from birth to age 4 years and fat deposition in metabolically distinct compartments at age 4.5 years in a South Asian longitudinal birth cohort.
methodsVolumetric abdominal magnetic resonance imaging with comprehensive segmentation of deep and superficial subcutaneous adipose tissue (SAT) and visceral adipose tissues (VAT) was performed in 316 children (150 boys and 166 girls in three ethnic groups; 158 Chinese, 94 Malay, and 64 Indian) aged 4.5 years. Associations between fat volumes and annual relative weight gain conditional on past growth were assessed overall and stratified by sex and ethnicity.
resultsConditional relative weight gain had stronger associations with greater SAT and VAT at age 4.5 years in girls than boys and in Indians compared with Malay and Chinese. Overall, the magnitude of association was the largest during 2 to 3 years for SAT and 1 to 2 years for VAT. Despite similar body weight, Indian children and girls had the highest deep and superficial SAT volumes at age 4.5 years (all interactions P < 0.05). No significant sex or ethnic differences were observed in VAT. With increasing BMI, Indian children had the highest tendency to accumulate VAT, and girls accumulated more fat than boys in all depots (all interactions P < 0.001).
conclusionsIndian ethnicity and female sex predisposed children to accumulate more fat in the VAT depot with increasing conditional relative weight gain in the second year of life. Thus, 1 to 2 years of age may be a critical window for interventions to reduce visceral fat accumulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.