ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2019
Antibiotic misuse in respiratory tract infections in children and adults-a prospective, multicentre study (TAILORED Treatment).
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 113 citations in OpenAlex.
- Trial
- Effect of Point-of-Care Testing for Respiratory Pathogens on Antibiotic Use in Children: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Probiotic Bifidobacterium lactis Probio-M8 treated and prevented acute RTI, reduced antibiotic use and hospital stay in hospitalized young children: a randomized, double-blind, placebo-controlled study.European journal of nutrition · 2022Trial
- Trial
- Global under- and overprescribing of drugs-a scoping review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Respiratory Pathogen Detection Among Febrile Inpatients in Northern Tanzania, 2016-2019.Open forum infectious diseases · 2026Article
- Antibiotic overuse in children with viral infections: lessons from the SARS-CoV-2 pandemic.BMJ paediatrics open · 2026Article
- Lung ultrasound combined with C-reactive protein for identifying a bacterial component in children hospitalized with acute lower respiratory tract infections: a prospective observational study.European journal of pediatrics · 2026Observational
- Exploring the Link Between RSV Infection and Antibiotic Prescriptions in Older Adults: A Systematic Review.Antibiotics (Basel, Switzerland) · 2026Review
- Article
- Social Determinants of Health and Antibiotic Consumption.Antibiotics (Basel, Switzerland) · 2025Article
- Antibiotic susceptibility of pathogens isolated in respiratory tract samples of recently hospitalized patients.Microbiology spectrum · 2025Article
- Etiology and Clinical Prediction of Community-Acquired Lower Respiratory Tract Infection in Children.Journal of Korean medical science · 2025Article
- Antibiotic prescription sources and use among under-5 children with fever/cough in sub-Saharan Africa.International health · 2025Article
- Respiratory infections in the post-COVID-19 era: impact, prevalence, and clinical characteristics of bacterial and viral co-infections.Frontiers in medicine · 2025Article
- National antibiotic consumption for human use in Chad (2017-2021): a descriptive cross-sectional study.Frontiers in antibiotics · 2025Article
- Respiratory virus-induced bacterial dysregulation in pediatric airway tissue and the dual actions of Echinacea in reducing complications.Frontiers in pharmacology · 2025Article
- Examination of unique volatile organic compound signatures in nasopharyngeal test swab viral transport media using an electronic nose.PloS one · 2025Article
- Clinical effects ofFrontiers in nutrition · 2025Article
- Antimicrobial resistance at a turning point: microbial drivers, one health, and global futures.Frontiers in microbiology · 2025Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
44 authors at 12 institutions in 4 countries.
Funding
Abstract
Respiratory tract infections (RTI) are more commonly caused by viral pathogens in children than in adults. Surprisingly, little is known about antibiotic use in children as compared to adults with RTI. This prospective study aimed to determine antibiotic misuse in children and adults with RTI, using an expert panel reference standard, in order to prioritise the target age population for antibiotic stewardship interventions. We recruited children and adults who presented at the emergency department or were hospitalised with clinical presentation of RTI in The Netherlands and Israel. A panel of three experienced physicians adjudicated a reference standard diagnosis (i.e. bacterial or viral infection) for all the patients using all available clinical and laboratory information, including a 28-day follow-up assessment. The cohort included 284 children and 232 adults with RTI (median age, 1.3 years and 64.5 years, respectively). The proportion of viral infections was larger in children than in adults (209(74%) versus 89(38%), p < 0.001). In case of viral RTI, antibiotics were prescribed (i.e. overuse) less frequently in children than in adults (77/209 (37%) versus 74/89 (83%), p < 0.001). One (1%) child and three (2%) adults with bacterial infection were not treated with antibiotics (i.e. underuse); all were mild cases. This international, prospective study confirms major antibiotic overuse in patients with RTI. Viral infection is more common in children, but antibiotic overuse is more frequent in adults with viral RTI. Together, these findings support the need for effective interventions to decrease antibiotic overuse in RTI patients of all ages.
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Registered trials
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