Evidence map›Paper›PMID 30707358›Full record

ArticleJournal of neurology2019

Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients.

Zhe Long, Muireann Irish, Olivier Piguet, Matthew C Kiernan, John R Hodges, James R Burrell

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Cognitive dysfunction in amyotrophic lateral sclerosis: can we predict it?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Speech and Language Presentations of FTLD-TDP Type B Neuropathology.Journal of neuropathology and experimental neurology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhe LongSydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Muireann IrishBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Olivier PiguetBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Matthew C KiernanSydney Medical School, The University of Sydney, Sydney, NSW, Australia.
John R HodgesSydney Medical School, The University of Sydney, Sydney, NSW, Australia.
James R BurrellBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. james.burrell@sydney.edu.au.
University of Sydney · AUARC Centre of Excellence in Cognition and its Disorders · AURoyal Prince Alfred Hospital · AU

Funding

Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders Memory Program CE110001021Australian Research Council (ARC) Future Fellowship FT160100096National Health and Medical Research Council of Australia (NHMRC) 1037746National Health and Medical Research Council of Australia (NHMRC) Early Career Fellowship 1072451National Health and Medical Research Council of Australia (NHMRC) Senior Research Fellowship APP1103258
6 · The paper itself

Abstract

This study systematically investigated the neuropsychological profile of language disturbance in frontotemporal dementia-motor neuron disease (FTD-MND) using a data-driven approach. Neuroanatomical correlates of language profiles were also examined. Patients with FTD-MND (N = 26), pure motor neuron disease (N = 34), progressive non-fluent aphasia (N = 30), semantic dementia (N = 17), and controls (N = 31) underwent comprehensive language assessments. Clinical assessments were complemented with the Sydney Language Battery (SYDBAT), to assess semantic abilities, and the Test for Reception of Grammar (TROG), to assess syntactic comprehension. Two-step cluster analysis examined patterns of language impairment in FTD-MND and voxel-based morphometry investigated neuroanatomical differences between clusters. Almost all (88.5%) FTD-MND patients had language impairment, with anomia in 73.1% and impaired sentence comprehension in 56%. Cluster analysis revealed two main profiles of language impairment in FTD-MND; a mild mixed semantic and syntactic impairment (mild mixed subgroup) seen in 12 cases and a subgroup with more marked impairment particularly of syntactic comprehension (PNFA-like subgroup) seen in 7 cases. VBM revealed disproportionate atrophy of the caudate head and putamen bilaterally in the PNFA-like subgroup. In conclusion, language disturbances in FTD-MND are heterogeneous and more mixed than seen in FTD language phenotypes. Atrophy of the caudate and putamen was correlated with disproportionate impairment of syntactic comprehension. A pure semantic dementia like syndrome appears to be rare in FTD-MND.

Indexed as

AgedBrainCluster AnalysisCohort StudiesCross-Sectional StudiesFemaleFrontotemporal DementiaHumansLanguageLanguage DisordersMaleMiddle AgedMotor Neuron DiseaseNeuroimagingNeuropsychological TestsBasal gangliaFrontotemporal dementia–motor neuron diseaseSemantic deficitsSyntactic comprehension dysfunction

Identifiers

PMID30707358
OpenAlexW2913013551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.