Evidence map›Paper›PMID 30707310›Full record

ArticleMikrochimica acta2019

Simultaneous colorimetric determination of acute myocardial infarction biomarkers by integrating self-assembled 3D gold nanovesicles into a multiple immunosorbent assay.

Qinli Pu, Xuanhua Yang, Yongcan Guo, Tao Dai, Tingyan Yang, Xinying Ou, Junlong Li, Shangchun Sheng, Guoming Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Qinli PuKey Laboratory of Laboratory Medical Diagnostics of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Xuanhua YangDepartment of Gastrointestinal Surgery, Second Clinical Medical Institution of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, 637000, People's Republic of China.
Yongcan GuoClinical Laboratory of Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Tao DaiKey Laboratory of Laboratory Medical Diagnostics of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Tingyan YangKey Laboratory of Laboratory Medical Diagnostics of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Xinying OuKey Laboratory of Laboratory Medical Diagnostics of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Junlong LiUniversity-Town Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Shangchun ShengClinical Laboratory of Hospital Affiliated to Chengdu University, Sichuan, 610081, People's Republic of China.
Guoming XieKey Laboratory of Laboratory Medical Diagnostics of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China. guomingxie@cqmu.edu.cn.
Chongqing Medical University · CNChengdu University · CNNorth Sichuan Medical University · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An improved enzyme-free immunosorbent assay is described for the simultaneous detection of the myocardial infarction biomarkers N-terminal pro B type natriuretic peptide (NT-proBNP), creatine kinase-MB (CK-MB), and cardiac muscle troponin T (cTnT). The assay integrates 3D gold nanovesicles (GNVs) and three allochroic agents (phenolphthalein, methyl red, bromothymol blue). The pH regulated allochroic agents were enwrapped in GNVs to acts as ultrasensitive nanoprobes. Loading can be controlled by adjusting the temperature to efficiently load and release the allochroic agents. This bare-eye multicolor assay has limits of detection of 70 pg·mL

Indexed as

BiomarkersBiosensing TechniquesColorimetryColoring AgentsCreatine Kinase, MB FormGoldHumansHydrogen-Ion ConcentrationImmunosorbentsLimit of DetectionMetal NanoparticlesMyocardial InfarctionMyocardiumNatriuretic Peptide, BrainParticle SizePeptide FragmentsBiomarkersColoring AgentsCreatine Kinase, MB FormGoldImmunosorbentsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin TAllochroic agentsCardiac muscle troponin TCreatine kinase-MBEnzyme-free immunosorbent assayGold nanovesiclesMultiplex detectionNanoprobesN-terminal pro B type natriuretic peptidePlasma samples

Identifiers

PMID30707310
OpenAlexW2913092879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.