Evidence map›Paper›PMID 30707177›Full record

ArticleChinese medical journal2019

Artificial intelligence system of faster region-based convolutional neural network surpassing senior radiologists in evaluation of metastatic lymph nodes of rectal cancer.

Lei Ding, Guang-Wei Liu, Bao-Chun Zhao, Yun-Peng Zhou, Shuai Li, Zheng-Dong Zhang, Yu-Ting Guo, Ai-Qin Li, Yun Lu, Hong-Wei Yao and 4 more

Abstract read
In one paragraph

Article in Chinese medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lei DingShandong Key Laboratory of Digital Medicine & Computer Assisted Surgery, Qingdao University, Qingdao, Shandong 266003, China.
Guang-Wei LiuShandong Key Laboratory of Digital Medicine & Computer Assisted Surgery, Qingdao University, Qingdao, Shandong 266003, China.
Bao-Chun ZhaoDepartment of Follow-up, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266003, China.
Yun-Peng ZhouDepartment of Gastroenterology Surgery, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266003, China.
Shuai LiState Key Laboratory of Virtual Reality Technology & Systems, Beihang University, Beijing 100191, China.
Zheng-Dong ZhangState Key Laboratory of Virtual Reality Technology & Systems, Beihang University, Beijing 100191, China.
Yu-Ting GuoState Key Laboratory of Virtual Reality Technology & Systems, Beihang University, Beijing 100191, China.
Ai-Qin LiDepartment of Outpatient Administration, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266003, China.
Yun LuShandong Key Laboratory of Digital Medicine & Computer Assisted Surgery, Qingdao University, Qingdao, Shandong 266003, China.
Hong-Wei YaoDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, Beijing 100050, China.
Wei-Tang YuanDepartment of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhenzhou, Henan 450052, China.
Gui-Ying WangDepartment of General Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.
Dian-Liang ZhangDepartment of General Surgery, Qingdao Municipal Hospital, Qingdao, Shandong 266011, China.
Lei WangDepartment of General Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510655, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn artificial intelligence system of Faster Region-based Convolutional Neural Network (Faster R-CNN) is newly developed for the diagnosis of metastatic lymph node (LN) in rectal cancer patients. The primary objective of this study was to comprehensively verify its accuracy in clinical use.

methodsFour hundred fourteen patients with rectal cancer discharged between January 2013 and March 2015 were collected from 6 clinical centers, and the magnetic resonance imaging data for pelvic metastatic LNs of each patient was identified by Faster R-CNN. Faster R-CNN based diagnoses were compared with radiologist based diagnoses and pathologist based diagnoses for methodological verification, using correlation analyses and consistency check. For clinical verification, the patients were retrospectively followed up by telephone for 36 months, with post-operative recurrence of rectal cancer as a clinical outcome; recurrence-free survivals of the patients were compared among different diagnostic groups, by methods of Kaplan-Meier and Cox hazards regression model.

resultsSignificant correlations were observed between any 2 factors among the numbers of metastatic LNs separately diagnosed by radiologists, Faster R-CNN and pathologists, as evidenced by rradiologist-Faster R-CNN of 0.912, rPathologist-radiologist of 0.134, and rPathologist-Faster R-CNN of 0.448 respectively. The value of kappa coefficient in N staging between Faster R-CNN and pathologists was 0.573, and this value between radiologists and pathologists was 0.473. The 3 groups of Faster R-CNN, radiologists and pathologists showed no significant differences in the recurrence-free survival time for stage N0 and N1 patients, but significant differences were found for stage N2 patients.

conclusionFaster R-CNN surpasses radiologists in the evaluation of pelvic metastatic LNs of rectal cancer, but is not on par with pathologists.

trial registrationwww.chictr.org.cn (No. ChiCTR-DDD-17013842).

Indexed as

Artificial IntelligenceNeural Networks, ComputerRadiologistsAdultAgedAged, 80 and overFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPathologistsRectal Neoplasms

Identifiers

PMID30707177
PMCPMC6595714

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.