ArticleThe British journal of radiology2019
Dose painting by dynamic irradiation delivery on an image-guided small animal radiotherapy platform.
Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Radiotherapy plus neoadjuvant and concomitant IL-13Rα2-directed immunotoxin therapy for diffuse intrinsic pontine glioma.Communications biology · 2026Article
- Retrospective analysis and IMRT replanning of a 3D-CRT murine dose painting study for preclinical oxygen-guided radiotherapy.Scientific reports · 2025Article
- Robust Automated Mouse Micro-CT Segmentation Using Swin UNEt TRansformers.Bioengineering (Basel, Switzerland) · 2024Article
- Understanding the impact of radiation-induced lymphopenia: Preclinical and clinical research perspectives.Clinical and translational radiation oncology · 2024Review
- Article
- An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation.Physics in medicine and biology · 2022Article
- Deep Learning Based Automated Orthotopic Lung Tumor Segmentation in Whole-Body Mouse CT-Scans.Cancers · 2021Article
- Small Animal IMRT Using 3D-Printed Compensators.International journal of radiation oncology, biology, physics · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective: Using synchronized three-dimensional stage translation and multiangle radiation delivery to improve conformality and homogeneity of radiation delivery to complexly shaped target volumes for precision preclinical radiotherapy.
methods: A CT image of a mouse was used to design irradiation plans to target the spinal cord and an orthotopic lung tumour. A dose painting method is proposed that combines heterogeneous two-dimensional area irradiations from multiple beam directions. For each beam direction, a two-dimensional area was defined based on the projection of the target volume. Each area was divided into many single beam Monte Carlo simulations, based on radiochromic film characterization of a 2.4 mm beam of a commercial precision image-guided preclinical irradiation platform. Beam-on time optimization including all simulated beams from multiple beam directions was used to achieve clinically relevant irradiation objects. Dose painting irradiation plans were compared to irradiation plans using a fixed aperture and rotatable variable aperture collimator.
results: Irradiation plans for the proposed dose painting approach achieved good target coverage, similar dose to avoidance structures in comparison with irradiation using a rotatable variable aperture collimator, and considerably less dose to avoidance volumes in comparison with irradiation using a non-rotatable fixed aperture collimator. Required calculations and beam-on times were considerably longer for the dose painting method.
conclusion: It was shown that the proposed dose painting strategy is a valuable extension to increase the versatility of current generation precision preclinical radiotherapy platforms. More conformal and homogeneous dose delivery may be achieved at the cost of increased radiation planning and delivery duration. ADVANCES IN KNOWLEDGE:: More advanced radiation planning for image-guided preclinical radiotherapy platforms can improve target dose conformality and homogeneity with the use of optimized dynamic irradiations with synchronized couch translation. The versatility of these platforms can be increased without hardware modifications.
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