Evidence map›Paper›PMID 30706700›Full record

ArticlePhysiological reports2019

FURIN variant associations with postexercise hypotension are intensity and race dependent.

Burak T Cilhoroz, Elizabeth D Schifano, Gregory A Panza, Garrett I Ash, Lauren Corso, Ming-Hui Chen, Ved Deshpande, Amanda Zaleski, Paulo Farinatti, Lucas P Santos and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  7. Diseases with health disparities as drivers of COVID-19 outcome.Journal of cellular and molecular medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Burak T CilhorozDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Elizabeth D SchifanoDepartment of Statistics, University of Connecticut, Storrs, Connecticut.
Gregory A PanzaDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Garrett I AshSchool of Nursing, Yale University, New Haven, Connecticut.ORCID 0000-0002-8655-7525
Lauren CorsoDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Storrs, Connecticut.
Ved DeshpandeDepartment of Statistics, University of Connecticut, Storrs, Connecticut.
Amanda ZaleskiDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Paulo FarinattiDepartment of Physical Activity Sciences, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Lucas P SantosDepartment of Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Beth A TaylorDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Rachel J O'NeillInstitute for Systems Genomics, University of Connecticut, Storrs, Connecticut.
Paul D ThompsonDepartment of Preventive Cardiology, Hartford Hospital, Hartford, Connecticut.
Linda S PescatelloDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
University of Connecticut · USHartford Hospital · USUniversidade do Estado do Rio de Janeiro · BRUniversidade Federal do Rio Grande do Sul · BRYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FURIN is a proprotein convertase subtilisin/kexin enzyme important in pro-renin receptor processing, and FURIN (furin, paired basic amino acid cleaving enzyme) variants are involved in multiple aspects of blood pressure (BP) regulation. Therefore, we examined associations among FURIN variants and the immediate blood pressure (BP) response to bouts of aerobic exercise, termed postexercise hypotension (PEH). Obese (30.9 ± 3.6 kg

Indexed as

ExercisePolymorphism, Single NucleotideAdolescentAdultBicyclingBlack or African AmericanBlood PressureCase-Control StudiesFemaleFurinGenetic Association StudiesGenetic Predisposition to DiseaseHumansHypertensionHypotensionMaleFurinFURIN protein, humanBlood Pressureexercisehypertensionpolymorphism

Identifiers

PMID30706700
PMCPMC6356167
OpenAlexW2914534893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.