ArticleCancer medicine2019
Impact of visceral pleural invasion on the association of extent of lymphadenectomy and survival in stage I non-small cell lung cancer.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Multi-component radiological model based on intratumoral CT threshold segmentation for predicting visceral pleural invasion in lung adenocarcinoma ≤ 30 mm.Insights into imaging · 2026Article
- Preoperative prediction of visceral pleural invasion in clinical stage T1 invasive lung adenocarcinoma using intratumoral and peritumoral radiomics: a multicenter development, validation, and comparison study.BMC medical imaging · 2026Article
- Risk factors for pathological invasiveness of non-mucinous invasive pulmonary adenocarcinoma with a maximum diameter of less than or equal to 3 cm in thin-section CT: a retrospective study.Scientific reports · 2026Article
- CT predictors of visceral pleural invasion in subsolid nodular pulmonary adenocarcinoma: differences between direct and indirect tumor-pleura contact.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Observational
- Integrated predictive model for visceral pleural invasion in small NSCLC with high clinical utility.NPJ precision oncology · 2026Article
- Contrast-enhanced CT-based radiomics for predicting visceral pleural invasion in early-stage non-small cell lung cancer.Insights into imaging · 2026Article
- Predicting Visceral Pleural Invasion in Resected Lung Adenocarcinoma via Computed Tomography.Cancers · 2025Article
- Prediction of visceral pleural invasion of clinical stage IA lung adenocarcinoma based on computed tomography features.Translational cancer research · 2025Article
- Tumour-pleura relationship on computed tomography (CT) provides effective risk stratification for peripheral pulmonary nodules with Lung Imaging Reporting and Data System (Lung-RADS) score of 4X.Quantitative imaging in medicine and surgery · 2024Article
- Nomogram using intratumoral and peritumoral radiomics for the preoperative prediction of visceral pleural invasion in clinical stage IA lung adenocarcinoma.Journal of cardiothoracic surgery · 2024Article
- Research progress in predicting visceral pleural invasion of lung cancer: a narrative review.Translational cancer research · 2024Review
- Multivariate analysis based on the maximum standard unit value ofDiagnostic and interventional radiology (Ankara, Turkey) · 2023Article
- CT-based radiomics nomogram for predicting visceral pleural invasion in peripheral T1-sized solid lung adenocarcinoma.American journal of cancer research · 2023Article
- Diagnosis, treatment, and prognosis of stage IB non-small cell lung cancer with visceral pleural invasion.Frontiers in oncology · 2023Review
- Effect of pleural invasion on survival of patients with small cell lung cancer: Propensity score analysis and nomogram establishment based on the SEER database.Frontiers in surgery · 2023Article
- Application of computed tomography-based radiomics combined with clinical factors in the diagnosis of malignant degree of lung adenocarcinoma.Journal of thoracic disease · 2022Article
- Is lobectomy superior to sub-lobectomy in non-small cell lung cancer with pleural invasion? A population-based competing risk analysis.BMC cancer · 2022Article
- Treatment Modality for Stage IB Peripheral Non-Small Cell Lung Cancer With Visceral Pleural Invasion and ≤3 cm in Size.Frontiers in oncology · 2022Article
- Exploration of the optimal number of regional lymph nodes removed for resected N0 NSCLC patients: A population-based study.Frontiers in oncology · 2022Article
- A Population-Based Study on the Prognostic factors and Efficacy of Adjuvant Chemotherapy in the Postoperative Stage for Patients with Stage IIA Non-Small Cell Lung Cancer.Risk management and healthcare policy · 2022Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral pleural invasion (VPI) has been identified as an adverse prognostic factor for non-small cell lung cancer (NSCLC). Accurate nodal staging for NSCLC correlates with improved survival, but it is unclear whether tumors with VPI require a more extensive lymph nodes (LNs) dissection to optimize survival. We aimed to evaluate the impact of VPI status on the optimal extent of LNs dissection in stage I NSCLC, using the Surveillance, Epidemiology, and End Results (SEER) database. We identified 9297 surgically treated T1-2aN0M0 NSCLC patients with at least one examined LNs. Propensity score matching was conducted to balance the baseline clinicopathologic characteristics between the VPI group and non-VPI group. Log-rank tests along with Cox proportional hazards regression methods were performed to evaluate the impact of extent of LNs dissection on survival. VPI was correlated with a significant worse survival, but there was no significant difference in survival rate between PL1 and PL2. Patients who underwent sublobectomy had slightly decreased survival than those who underwent lobectomy. Pathologic LNs examination was significantly correlated with survival. Examination of 7-8 LNs and 14-16 LNs conferred the lowest hazard ratio for T1-sized/non-VPI tumors (stage IA) and T1-sized/VPI tumors (stage IB), respectively. The optimal extent of LNs dissection varied by VPI status, with T1-sized/VPI tumors (stage IB) requiring a more extensive LNs dissection than T1-sized/non-VPI tumors (stage IA). These results might provide guidelines for surgical procedure in early stage NSCLC.
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