Evidence map›Paper›PMID 30706617›Full record

ArticleVeterinary ophthalmology2019

Equine eosinophilic keratoconjunctivitis in California: retrospective study of 47 eyes from 29 cases (1993-2017).

Kelly E Knickelbein, Daniela Luethy, Sara M Thomasy, Christopher Reilly, Ann R Strom, Mary E Lassaline

Open access · greenAbstract readCase Reports
In one paragraph

Article in Veterinary ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Kelly E KnickelbeinVeterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, California.
Daniela LuethyNew Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania.
Sara M ThomasyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.
Christopher ReillyInsight Veterinary Specialty Pathology, Austin, Texas.
Ann R StromMalmö Djursjukhus, Malmö, Sweden.
Mary E LassalineDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.
University of California, Davis · USGenesis HealthCare · USMalmö Municipality · SESpecialty Materials (United States) · USVeterinary Medical Teaching Hospital · US

Funding

Engineering the Corneal Wound Bed to Promote HealingK08EY021142 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI THOMASY, SARA MICHELLE · 2011 to 2015
$879k
National Institutes of Health K08 EY021142NEI NIH HHS K08 EY021142
6 · The paper itself

Abstract

objective(a) To evaluate the epidemiology of equine eosinophilic keratoconjunctivitis (EK) in the western United States, (b) to ascertain the efficacy of keratectomy and diamond burr debridement vs medical management alone, (c) to determine the efficacy of various medical therapies, and (d) to further characterize the histopathologic findings of the disease in horses. ANIMALS STUDIED: Twenty-nine horses (47 eyes) diagnosed with EK from 1993 to 2017. PROCEDURE: Retrospective medical record review; owner questionnaire.

resultsAverage age of presentation was 11 ± 4 years. Warmbloods were significantly overrepresented (P = 0.024). Twenty horses were treated with medical therapy alone, five were treated with superficial lamellar keratectomy, and four were treated with diamond burr debridement. Follow-up data were available for 38 eyes of 23 horses. Median time to resolution for horses treated with either superficial keratectomy or diamond burr debridement (62 days) was not statistically significantly different from those that underwent medical therapy alone (46 days; P = 0.33). Eyes treated with topical steroids had a statistically significant longer median time to resolution (61 days) compared to those that did not receive topical steroid (44 days; P = 0.023). Common histopathologic findings in keratectomy samples included the presence of eosinophils, vascularization, and an eosinophilic membrane spanning areas of ulceration.

conclusionIn this population, time to EK resolution was similar for horses treated with medical and surgical management. The use of topical steroids was associated with a prolonged time to resolution. Keratectomy samples from horses with EK had similar findings to those reported in other species.

Indexed as

AnimalsCaliforniaDebridementEosinophiliaFemaleFollow-Up StudiesHorse DiseasesHorsesKeratoconjunctivitisMaleRetrospective StudiesSteroidsSteroidsallergycorneal ulcergranulocytehorsekeratectomy

Identifiers

PMID30706617
PMCPMC6635066
OpenAlexW2911848789

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.