ReviewTraffic (Copenhagen, Denmark)2019
Glycosylation and glycan interactions can serve as extracellular machinery facilitating clathrin-independent endocytosis.
Review in Traffic (Copenhagen, Denmark), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2-Deoxyglucose.Angewandte Chemie (International ed. in English) · 2026Article
- Glycoproteomics analysis of colorectal cancer reveals differential alterations of glycoproteins and glycans.Analytical and bioanalytical chemistry · 2025Article
- Spatial N-glycan rearrangement on αNature communications · 2025Article
- Sugar unmasking for trafficking.Nature cell biology · 2025Article
- The interaction of Galectin-8 C-terminal domain with cell surface glycoconjugates modulates membrane elasticity to stimulate antigen uptake and presentation to CD4 T cells.Journal of leukocyte biology · 2025Article
- The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis.Cell communication and signaling : CCS · 2024Article
- Endocytic Roles of Glycans on Proteins and Lipids.Cold Spring Harbor perspectives in biology · 2024Review
- Review
- Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge.Journal of the American Chemical Society · 2022Article
- Evaluating the Role of Galectins in Clathrin-Independent Endocytosis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Cyanovirin-N Binds Viral Envelope Proteins at the Low-Affinity Carbohydrate Binding Site without Direct Virus Neutralization Ability.Molecules (Basel, Switzerland) · 2021Article
- Differential Glycosite Profiling-A Versatile Method to Compare Membrane Glycoproteomes.Molecules (Basel, Switzerland) · 2021Article
- Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes.Communications biology · 2021Article
- Galectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing.iScience · 2020Article
- Molecular mechanism of Fast Endophilin-Mediated Endocytosis.The Biochemical journal · 2020Review
- Glycosylation and raft endocytosis in cancer.Cancer metastasis reviews · 2020Review
- On the existence of endocytosis driven by membrane phase separations.Biochimica et biophysica acta. Biomembranes · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In contrast to clathrin-mediated endocytosis (CME) which is well characterized and understood, little is known about the regulation and machinery underlying clathrin-independent endocytosis (CIE). There is also a wide variation in the requirements each individual CIE cargo has for its internalization. Recent studies have shown that CIE is affected by glycosylation and glycan interactions. We briefly review these studies and explore how these studies mesh with one another. We then discuss what this sensitivity to glycan interactions could indicate for the regulation of CIE. We address the spectrum of responses CIE has been shown to have with respect to changes in glycan interactions and attempt to reconcile disparate observations onto a shared conceptual landscape. We focus on the mechanisms by which cells can alter the glycan interactions at the plasma membrane and propose that glycosylation and glycan interactions could provide cells with a tool box with which cells can manipulate CIE. Altered glycosylation is often associated with a number of diseases and we discuss how under different disease settings, glycosylation-based modulation of CIE could play a role in disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.