ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2019
Super-Resolution Ultrasound Imaging of Skeletal Muscle Microvascular Dysfunction in an Animal Model of Type 2 Diabetes.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.Circulation research · 2026Review
- Super-resolution ultrasound imaging reveals microvascular alterations in joint capsule of dysplastic hip: a rabbit model study.BMC musculoskeletal disorders · 2026Article
- Differentiation of benign and malignant breast lesions by ultrasound localization microscopy.Insights into imaging · 2025Article
- Progresses and clinical application of super-resolution ultrasound imaging: a narrative review.The ultrasound journal · 2025Review
- OptimizingPhysics in medicine and biology · 2025Article
- Ultrasound localization microscopy in the diagnosis of breast tumors and prediction of relevant histologic biomarkers associated with prognosis in humans: the protocol for a prospective, multicenter study.BMC medical imaging · 2025Article
- Article
- Critical Advances for Democratizing Ultrasound Diagnostics in Human and Veterinary Medicine.Annual review of biomedical engineering · 2024Review
- Super-Resolution Ultrasound Imaging for Monitoring the Therapeutic Efficacy of a Vascular Disrupting Agent in an Animal Model of Breast Cancer.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024Article
- Super-resolution techniques for biomedical applications and challenges.Biomedical engineering letters · 2024Review
- Comparison of micro-CT image enhancement after use of different vascular casting agents.Quantitative imaging in medicine and surgery · 2024Article
- Three-dimensional super resolution ultrasound imaging with a multi-frequency hemispherical phased array.Medical physics · 2023Article
- Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle.Nature communications · 2023Article
- Ultrasound localization microscopy.Zeitschrift fur medizinische Physik · 2023Review
- Assessment of Transarterial Chemoembolization Using Super-resolution Ultrasound Imaging and a Rat Model of Hepatocellular Carcinoma.Ultrasound in medicine & biology · 2023Article
- Generalized mathematical framework for contrast-enhanced ultrasound imaging with pulse inversion spectral deconvolution.Ultrasonics · 2023Article
- Super-Resolution Ultrasound Imaging Provides Quantification of the Renal Cortical and Medullary Vasculature in Obese Zucker Rats: A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- A Review of Clinical Applications for Super-resolution Ultrasound Localization Microscopy.Current medical science · 2022Review
- Compressed Sensing-Based Super-Resolution Ultrasound Imaging for Faster Acquisition and High Quality Images.IEEE transactions on bio-medical engineering · 2021Article
- Evaluation of Nonlinear Contrast Pulse Sequencing for Use in Super-Resolution Ultrasound Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo evaluate the use of super-resolution ultrasound (SR-US) imaging for quantifying microvascular changes in skeletal muscle using a mouse model of type 2 diabetes.
methodsStudy groups were young, standard chow-fed male C57BL/6J mice (lean group) and high fat diet-fed older mice (obese group). After an overnight fast, dynamic contrast-enhanced US imaging was performed on the proximal hind limb adductor muscle group for 10 minutes at baseline and again at 1 and 2 hours during administration of a hyperinsulinemic-euglycemic clamp. Dynamic contrast-enhanced US images were collected on a clinical US scanner (Acuson Sequoia 512; Siemens Healthcare, Mountain View, CA) equipped with a 15L8 linear array transducer. Dynamic contrast-enhanced US images were processed with a spatiotemporal filter to remove tissue clutter. Individual microbubbles were localized and counted to create an SR-US image. A frame-by-frame analysis of the microbubble count was generated (ie, time-microbubble count curve [TMC]) to estimate tissue perfusion and microvascular blood flow. The conventional time-intensity curve (TIC) was also generated for comparison.
resultsIn vivo SR-US imaging could delineate microvascular structures in the mouse hind limb. Compared with lean animals, insulin-induced microvascular recruitment was attenuated in the obese group. The SR-US-based TMC analysis revealed differences between lean and obese animal data for select microvascular parameters (P < .04), which was not true for TIC-based measurements. Whereas the TMC and TIC microvascular parameters yielded similar temporal trends, there was less variance associated with the TMC-derived values.
conclusionsSuper-resolution US imaging is a new modality for measuring the microvascular properties of skeletal muscle and dysfunction from type 2 diabetes.
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