Trial reportAlimentary pharmacology & therapeutics2019
Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers.
Trial report in Alimentary pharmacology & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Effect of fruit intake on functional constipation: A systematic review and meta-analysis of randomized and crossover studies.Frontiers in nutrition · 2022Pooled it
- Kiwifruit and Kiwifruit Extracts for Treatment of Constipation: A Systematic Review and Meta-Analysis.Canadian journal of gastroenterology & hepatology · 2022Pooled it
- Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.Clinical pharmacology and therapeutics · 2025Trial
- Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers.Alimentary pharmacology & therapeutics · 2019Trial
- Length of the Adult Human Colon in Health and Constipation Measured Using Magnetic Resonance Imaging.Neurogastroenterology and motility · 2026Article
- Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study.JMIR research protocols · 2026Article
- Randomized, Placebo-Controlled, Double-Blind 8-Week Trial on the Efficacy of A Proprietary Kiwifruit Extract on Constipation-Predominant Irritable Bowel Syndrome.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Review
- Exploring how researchers consider nutrition trial design and participant adherence: a theory-based analysis.Frontiers in nutrition · 2024Article
- The Impact of Nutritional Therapy on Gastrointestinal Motility in Older Adults.Healthcare (Basel, Switzerland) · 2023Review
- Non-Digestible Carbohydrates: Green Extraction from Food By-Products and Assessment of Their Effect on Microbiota Modulation.Nutrients · 2023Review
- Habitual Green Kiwifruit Consumption Is Associated with a Reduction in Upper Gastrointestinal Symptoms: A Systematic Scoping Review.Advances in nutrition (Bethesda, Md.) · 2022Article
- Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers.Pharmaceutics · 2022Article
- Intrinsic dietary fibers and the gut microbiome: Rediscovering the benefits of the plant cell matrix for human health.Frontiers in immunology · 2022Review
- Understanding the physiology of human defaecation and disorders of continence and evacuation.Nature reviews. Gastroenterology & hepatology · 2021Review
- Green kiwifruit (lat.EFSA journal. European Food Safety Authority · 2021Article
- Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.Diagnostics (Basel, Switzerland) · 2021Article
- Impact of Diet on Symptoms of the Irritable Bowel Syndrome.Nutrients · 2021Review
- The effect of green kiwifruit on gas transit and tolerance in healthy humans.Neurogastroenterology and motility · 2020Article
- Intraluminal Impact of Food: New Insights from MRI.Nutrients · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChronic constipation affects approximately 17% of the population worldwide and remains an important unmet need since patients are often dissatisfied with treatment. Kiwifruit may offer an alternative to traditional laxatives and have been shown to increase stool volume, frequency and improve consistency.
aimsUsing non-invasive MRI techniques, we assessed the effect of ingestion of kiwifruit on fluid distribution in the intestines and bowel function.
methodsTwo period crossover trial of kiwifruit vs control in healthy adults.
interventiontwo kiwifruits twice daily vs isocaloric control (maltodextrin) twice daily, consumed for a total of 3 days. Subjects underwent MRI scanning fasted and at hourly intervals for 7 hours on the third day. PRIMARY OUTCOME: T1 relaxation time of ascending colon (T1AC) using MRI. SECONDARY OUTCOMES: Small bowel water content (SBWC), colonic volume, gut transit time, T1 of descending colon, stool frequency and form.
resultsFourteen volunteers completed the study. T1AC was higher after kiwifruit ingestion (P = 0.029) during the second half of the day (when meal residue would be expected to reach the AC, AUC T1 T240-420 minutes; mean (SD) 137 (39) s*minute with kiwifruit versus 108 (40) s*minute with control. SBWC (P < 0.001), colon volumes (P = 0.004), as well as stool frequency (1.46 ± 0.66 with kiwifruit vs 1.14 ± 0.46 stools per day with control; P = 0.034) and stool form score (Bristol Stool Chart score 4.1 (0.9) with kiwifruit versus 3.4 (0.7) with control; P = 0.011) were markedly increased in participants consuming kiwifruit compared to control.
conclusionConsumption of kiwifruit in healthy volunteers increases water retention in the small bowel and ascending colon and increases total colonic volume. The data may explain the observed increase in stool frequency and looser stool consistencies, suggesting that kiwifruit could be used as a dietary alternative to laxatives in mild constipation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.