ArticleAmerican journal of physical anthropology2019
Age-related decline in urine concentration may not be universal: Comparative study from the U.S. and two small-scale societies.
Article in American journal of physical anthropology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Detecting disease associated biomarkers by luminescence modulating phages.Scientific reports · 2022Trial
- Urinary Hydration Biomarkers and Water Sources in Older Adults with Neurocognitive Disorder.Nutrients · 2023Article
- Cross-cultural variation in thirst perception in hot-humid and hot-arid environments: Evidence from two small-scale populations.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Drinking water salinity is associated with hypertension and hyperdilute urine among Daasanach pastoralists in Northern Kenya.The Science of the total environment · 2021Article
- Hydration in relation to water insecurity, heat index, and lactation status in two small-scale populations in hot-humid and hot-arid environments.American journal of human biology : the official journal of the Human Biology Council · 2021Article
- Measuring Human Water Needs.American journal of human biology : the official journal of the Human Biology Council · 2020Article
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Authors and funding
6 authors.
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Abstract
objectivesEvidence from industrialized populations suggests that urine concentrating ability declines with age. However, lifestyle factors including episodic protein intake and low hypertension may help explain differences between populations. Whether this age-related decline occurs among small-scale populations with active lifestyles and non-Western diets is unknown. We test the universality of age-related urine concentration decline. MATERIALS AND
methodsWe used urine specific gravity (Usg) and urine osmolality (Uosm) data from 15,055 U.S. nonpregnant adults without kidney failure aged 18-80 in 2007-2012 participating in the National Health and Nutrition Examination Survey (NHANES). We tested the relationship of age on urine concentration biomarkers with multiple linear regressions using survey commands. We compared results to longitudinal data on Usg from 116 Tsimane' forager-horticulturalists (266 observations) adults aged 18-83 in 2013-2014 from Lowland Bolivia, and to 38 Hadza hunter-gatherers (156 observations) aged 18-75 in 2010-2015 from Tanzania using random-effects panel linear regressions.
resultsAmong U.S. adults, age was significantly negatively associated with Usg (Adjusted beta [B] = -0.0009 g/mL/10 years; SE = 0.0001; p < 0.001) and Uosm (B = -28.1 mOsm/kg/10 yr; SE = 2.4; p < 0.001). In contrast, among Tsimane' (B = 0.0003 g/mL/10 yr; SE = 0.0002; p = 0.16) and Hadza (B = -0.0004 g/mL/10 yr; SE = 0.0004; p = 0.29) age was not associated with Usg. Older Tsimane' and Hadza exhibited similar within-individual variability in Usg equivalent to younger adults. DISCUSSION: While U.S. adults exhibited age-related declines in urine concentration, Tsimane' and Hadza adults did not exhibit the same statistical decline in Usg. Mismatches between evolved physiology and modern environments in lifestyle may affect kidney physiology and disease risk.
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