Trial reportThe British journal of surgery2019
Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer.
Trial report in The British journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04372992 (Multicenter Randomized Controlled Phase III Trial Comparing Ileostomy Closure Before or After Adjuvant Therapy in Patients Operated for Rectal Cancer), which is not on this map. Cited by 45 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Randomized Controlled Phase III Trial Comparing Ileostomy Closure Before or After Adjuvant Therapy in Patients Operated for Rectal Cancer
Who cites it
45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Early versus late closure of protective ileostomy after rectal cancer surgery.International journal of colorectal disease · 2026Pooled it
- A systematic review of preoperative radiological factors associated with the development of low anterior resection syndrome (LARS).Updates in surgery · 2025Pooled it
- Preventative strategies for low anterior resection syndrome.Techniques in coloproctology · 2023Pooled it
- Early versus delayed defunctioning ileostomy closure after low anterior resection for rectal cancer: a meta-analysis and trial sequential analysis of safety and functional outcomes.International journal of colorectal disease · 2022Pooled it
- The incidence and risk factors of low anterior resection syndrome (LARS) after sphincter-preserving surgery of rectal cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis.Techniques in coloproctology · 2021Pooled it
- Quality of life following ileostomy takedown: single-centre, retrospective clinical trial-does closure time matter?Techniques in coloproctology · 2025Trial
- Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics.Biomolecules · 2021Trial
- Trial
- Trial
- Optimal timing of ileostomy closure after rectal surgery: A Bayesian network meta-analysis of randomized controlled trials.Langenbeck's archives of surgery · 2026Review
- Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.Surgical endoscopy · 2026Article
- Effect and influencing factors of early ileostomy closure 2-4 weeks on patients with rectal cancer.Frontiers in oncology · 2026Article
- Low anterior resection syndrome after rectal cancer surgery: mechanisms, assessment, management, and the potential role of robotic surgery.Frontiers in oncology · 2026Review
- Double-tube end ileostomy: an alternative to classical defunctioning stoma in rectal surgery.Techniques in coloproctology · 2025Article
- Effectiveness of transanal irrigation in low anterior resection syndrome.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Functional outcomes and quality of life after intersphincteric resection with transverse coloplasty pouch anastomosis for ultralow rectal cancer: a prospective cohort study.Techniques in coloproctology · 2025Article
- Effect of one-stitch method of temporary ileostomy on the surgical outcomes and complications after laparoscopic low anterior resection in rectal cancer patients: a propensity score matching analysis.European journal of medical research · 2025Article
- Independent risk factors for diversion colitis: a retrospective case-control study.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Impact of the Timing of Protective Stoma Reversal on Survival in Rectal Cancer Patients Undergoing Postoperative Adjuvant Chemotherapy: A Retrospective Single Center Study.Cancer management and research · 2025Article
Corrections and comments
- Commented on byCorrespondence.2019
- Commented on byCorrespondence.2019
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow anterior resection syndrome (LARS) has a significant impact on postoperative quality of life. Although early closure of an ileostomy is safe in selected patients, functional outcomes have not been investigated. The aim was to compare bowel function and the prevalence of LARS in patients who underwent early or late closure of an ileostomy after rectal resection for cancer.
methodsEarly closure (8-13 days) was compared with late closure (after 12 weeks) of the ileostomy following rectal cancer surgery in a multicentre RCT. Exclusion criteria were: signs of anastomotic leakage, diabetes mellitus, steroid treatment and postoperative complications. Bowel function was evaluated using the LARS score and the Memorial Sloan Kettering Cancer Center Bowel Function Instrument (BFI).
resultsFollowing index surgery, 112 participants were randomized (55 early closure, 57 late closure). Bowel function was evaluated at a median of 49 months after stoma closure. Eighty-two of 93 eligible participants responded (12 had died and 7 had a permanent stoma). Rates of bowel dysfunction were higher in the late closure group, but this did not reach statistical significance (major LARS in 29 of 40 participants in late group and 25 of 42 in early group, P = 0·250; median BFI score 63 versus 71 respectively, P = 0·207). Participants in the late closure group had worse scores on the urgency/soiling subscale of the BFI (14 versus 17; P = 0·017). One participant in the early group and six in the late group had a permanent stoma (P = 0·054).
conclusionPatients undergoing early stoma closure had fewer problems with soiling and fewer had a permanent stoma, although reduced LARS was not demonstrated in this cohort. Dedicated prospective studies are required to evaluate definitively the association between temporary ileostomy, LARS and timing of closure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.