ArticleProgress in biomaterials2019
A silk fibroin/decellularized extract of Wharton's jelly hydrogel intended for cartilage tissue engineering.
Article in Progress in biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Decellularized cartilage scaffolds derived from wharton's jelly facilitate cartilage regeneration and inhibit angiogenesis.Materials today. Bio · 2025Article
- Decellularized Umbilical Cord as a Scaffold to Support Healing of Full-Thickness Wounds.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering.Gels (Basel, Switzerland) · 2023Review
- Glucose-Responsive Silk Fibroin Microneedles for Transdermal Delivery of Insulin.Biomimetics (Basel, Switzerland) · 2023Article
- Successful 3D culture and transplantation of mouse isolated preantral follicles in hydrogel of bioengineered Wharton's jelly.PloS one · 2023Article
- Decellularized Human Umbilical Tissue-Derived Hydrogels Promote Proliferation and Chondrogenic Differentiation of Mesenchymal Stem Cells.Bioengineering (Basel, Switzerland) · 2022Article
- Injectable adipose-derived stem cells-embedded alginate-gelatin microspheres prepared by electrospray for cartilage tissue regeneration.Journal of orthopaedic translation · 2022Article
- Placental Tissues as Biomaterials in Regenerative Medicine.BioMed research international · 2022Review
- Characterization of an Innovative Biomaterial Derived From Human Wharton's Jelly as a New Promising Coating for Tissue Engineering Applications.Frontiers in bioengineering and biotechnology · 2022Article
- Decellularization of Wharton's Jelly Increases Its Bioactivity and Antibacterial Properties.Frontiers in bioengineering and biotechnology · 2022Article
- A composite scaffold of Wharton's jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee.Journal of materials science. Materials in medicine · 2021Article
- Potential and recent advances of microcarriers in repairing cartilage defects.Journal of orthopaedic translation · 2021Review
- Extracellular Matrix From Decellularized Wharton's Jelly Improves the Behavior of Cells From Degenerated Intervertebral Disc.Frontiers in bioengineering and biotechnology · 2020Article
- Effect of detergent type on the performance of liver decellularized extracellular matrix-based bio-inks.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hybrid hydrogel was obtained from decellularized extract from Wharton's jelly (DEWJ) and silk fibroin (SF) and characterized for cartilage tissue engineering. Wharton's jelly was used due to its similarity with articular cartilage in extracellular matrix composition. Also, silk fibroin has good mechanical properties which make this construct appropriate for cartilage repair. Decellularization of Wharton's jelly was verified by DAPI staining, DNA quantification, and PCR analysis. Then, the biochemical composition of DEWJ was determined by ELISA kits for total proteins, collagens, sulfated glycosaminoglycans (sGAG), and transforming growth factor β1 (TGF-β1). After fabricating pure SF and SF/DEWJ hybrid hydrogels, their physical and mechanical properties were characterized by FESEM, Fourier-transform infrared spectroscopy (FTIR) and rheological assays (amplitude and frequency sweeps). Furthermore, cell viability and proliferation were assessed by MTT assay. The results have shown that DEWJ in hybrid hydrogels enhances mechanical properties of the construct relative to pure SF hydrogels. Also, this extract at its 40% concentration in culture media and 20% or 40% concentrations in SF/DEWJ hybrid hydrogels significantly increases population of the cells compared to control and pure SF hydrogel after 7 days. In conclusion, this study proposes the potential of SF/DEWJ hybrid hydrogels for cartilage tissue engineering applications.
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