ArticlePsychopharmacology2019
Increased motor impulsivity in a rat gambling task during chronic ropinirole treatment: potentiation by win-paired audiovisual cues.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- The Effect of Dopaminergic Medication on Impulse Control and Compulsive Behaviour: A Translational Perspective.Basic & clinical pharmacology & toxicology · 2026Review
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Impulsive-compulsive behaviours and striatal neuroactivity in mildly parkinsonian rats under D2/3 agonist and L-DOPA treatment.NPJ Parkinson's disease · 2025Article
- From Nutritional Patterns to Behavior: High-Fat Diet Influences on Inhibitory Control, Brain Gene Expression, and Metabolomics in Rats.ACS chemical neuroscience · 2024Article
- The neuropharmacological profile of interval responding during operant tasks.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The effects of early life stress on impulsivity.Neuroscience and biobehavioral reviews · 2022Review
- Noradrenergic contributions to cue-driven risk-taking and impulsivity.Psychopharmacology · 2021Article
- Impulse Control Disorders in Parkinson's Disease: From Bench to Bedside.Frontiers in neuroscience · 2021Review
- Using rodent models to understand interactions between gambling and substance use.Current opinion in behavioral sciences · 2020Article
- Translating concepts of risk and loss in rodent models of gambling and the limitations for clinical applications.Current opinion in behavioral sciences · 2020Article
- Challenges and Opportunities in Animal Models of Gambling-like Behavior.Current opinion in behavioral sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleChronic administration of D
objectivesWe aimed to assess the effect of chronic ropinirole in animal models that attempt to capture critical aspects of commercial gambling, including the risk of losing rather than failing to gain, and the use of win-paired sensory stimuli heavily featured in electronic gambling machines (EGMs).
methodsMale Long-Evans rats learned the rat gambling task (rGT; n = 24), in which animals sample between four options that differ in the magnitude and probability of rewards and time-out punishments. In the cued rGT (n = 40), reward-concurrent audiovisual cues were added that scaled in complexity with win size. Rats were then implanted with an osmotic pump delivering ropinirole (5 mg/kg/day) or saline for 28 days.
resultsChronic ropinirole did not unequivocally increase preference for more uncertain outcomes in either the cued or uncued rGT. Ropinirole transiently increased premature responses, a measure of motor impulsivity, and this change was larger and more long-lasting in the cued task.
conclusionsThese data suggest that explicitly signaling loss prevents the increase in preference for uncertain rewards caused by D
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.