ArticleImmunoHorizons2018
Attrition of T Cell Zone Fibroblastic Reticular Cell Number and Function in Aged Spleens.
Article in ImmunoHorizons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Compartment-specific regulation of stromal differentiation of the spleen in health and disease.Genes and immunity · 2026Review
- Review
- Tertiary lymphoid structures in neuroinflammation coordinate neuroimmune homeostasis and pathological progression.Journal of neuroinflammation · 2026Review
- Comprehensive characterisation of age-related changes in cell subpopulations and tissue structural properties in secondary lymphoid organs.Cell death & disease · 2025Article
- Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models.Zoological research · 2024Review
- Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging.Seminars in immunology · 2023Review
- Aging of lymphoid stromal architecture impacts immune responses.Seminars in immunology · 2023Review
- The aging of the immune system and its implications for transplantation.GeroScience · 2023Review
- Impact of senolytic treatment on immunity, aging, and disease.Frontiers in aging · 2023Review
- Reduced immunogenicity of a liveFrontiers in immunology · 2023Article
- How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions.Trends in molecular medicine · 2022Review
- Targeting TLR4 during vaccination boosts MAdCAM-1Science immunology · 2022Article
- Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cellular senescence is a key mediator of lung aging and susceptibility to infection.Frontiers in immunology · 2022Review
- Mechanisms underpinning poor antibody responses to vaccines in ageing.Immunology letters · 2022Review
- Article
- Lymphoid stromal cells-more than just a highway to humoral immunity.Oxford open immunology · 2021Review
- The Dynamics of B Cell Aging in Health and Disease.Frontiers in immunology · 2021Review
- Naïve T Cell Quiescence in Immune Aging.Advances in geriatric medicine and research · 2021Article
- Influence of immune aging on vaccine responses.The Journal of allergy and clinical immunology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Aging has a profound impact on multiple facets of the immune system, culminating in aberrant functionality. The architectural disorganization of splenic white pulp is a hallmark of the aging spleen, yet the factors underlying these structural changes are unclear. Fibroblastic reticular cells comprise one stromal cell subset in the spleen that is important for maintenance of architectural organization, yet it remains to be determined how aging impacts these cells. In this study, we sought to determine how aging impacts splenic T cell zone reticular cell (TRC) numbers, morphology, and function. Using a mouse model of aging, we found that aged naive spleens have fewer TRCs than young spleens. This reduction in TRC number correlated with reduced CCL19 and CCL21 concentrations in aged spleens, which may contribute to impaired homing of T cells. CCL21 in both young and aged spleens localized with TRCs. Aged TRCs extended marginally into B cell follicles and may contribute to the blending of the T cell zone and B cell follicles in aged spleens. The described age-related changes in TRCs number and function may be an underlying factor contributing to impaired immune system function with age.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.