Evidence map›Paper›PMID 30706009›Full record

ArticleAdvances in radiation oncology

Analysis of MRI Volumetric Changes After Hypofractionated Stereotactic Radiation Therapy for Benign Intracranial Neoplasms.

Kathryn R Fega, Geoffrey P Fletcher, Mark R Waddle, Jennifer L Peterson, Jonathan B Ashman, David M Barrs, Bernard R Bendok, Naresh P Patel, Alyx B Porter, Sujay A Vora

Open access · goldAbstract read
In one paragraph

Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Radiotherapy and radiosurgery for meningiomas.Neuro-oncology advances · 2023
    Article
  7. Radiotherapy for meningiomas.Journal of neuro-oncology · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kathryn R FegaDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona.
Geoffrey P FletcherDepartment of Radiology, Mayo Clinic Hospital, Phoenix, Arizona.
Mark R WaddleDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, Florida.
Jennifer L PetersonDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, Florida.
Jonathan B AshmanDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona.
David M BarrsDepartment of Otolaryngology, Head and Neck Surgery, Mayo Clinic Hospital, Phoenix, Arizona.
Bernard R BendokDepartment of Neurologic Surgery, Mayo Clinic Hospital, Phoenix, Arizona.
Naresh P PatelDepartment of Neurologic Surgery, Mayo Clinic Hospital, Phoenix, Arizona.
Alyx B PorterDepartment of Neurology, Mayo Clinic Hospital, Phoenix, Arizona.
Sujay A VoraDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona.
Mayo Clinic Hospital · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo quantitatively assess volumetric changes after hypofractionated stereotactic radiation therapy (HFSRT) in patients treated for vestibular schwannomas and meningiomas. METHODS AND MATERIALS: We retrospectively reviewed records of patients treated with HFSRT at our institution from 2002 to 2014. Patients received a median dose of 25 Gy in 5 fractions. After treatment, they underwent clinical and radiologic follow-up with magnetic resonance imaging (MRI) at 3- to 12-month intervals. Gross tumor volume was outlined on each thin slice of contrast-enhanced T1 series before and on each scan after HFSRT. Volumetric changes were calculated and compared with neuroradiologist interpretations.

resultsForty-three patients underwent 182 MRI scans. Tumor types included vestibular schwannoma (n = 34) and meningioma (n = 9). Median follow-up time was 29 months. Median gross tumor volume was 3.1 cm

conclusionsHFSRT is associated with excellent local control and a low incidence of toxicity. With volumetric MRI measurement, transient volume expansion was a common finding and was associated with temporary adverse effects. Although the neuroradiologist's interpretation generally agreed with the volumetric MRI measurement, the overall 15% discordance rate emphasizes the potential benefit of considering volumetric measurements, which may help clinicians correlate posttreatment symptoms with MRI findings.

Identifiers

PMID30706009
PMCPMC6349623
OpenAlexW2888758201

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.