Evidence map›Paper›PMID 30705983›Full record

ArticleHeliyon2019

Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40.

Diane N Ignacio, Kimberly D Mason, Ezra C Hackett-Morton, Christopher Albanese, Lymor Ringer, William D Wagner, Paul C Wang, Michael A Carducci, Sushant K Kachhap, Channing J Paller and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Heat Shock Proteins in Benign Prostatic Hyperplasia and Prostate Cancer.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

Diane N IgnacioHoward University Cancer Center, Washington DC 20060, United States.
Kimberly D MasonHoward University Cancer Center, Washington DC 20060, United States.
Ezra C Hackett-MortonHoward University Cancer Center, Washington DC 20060, United States.
Christopher AlbaneseLombardi Cancer Center, Georgetown University Medical Center, Washington DC, United States.
Lymor RingerLombardi Cancer Center, Georgetown University Medical Center, Washington DC, United States.
William D WagnerDepartment of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Paul C WangHoward University Cancer Center, Washington DC 20060, United States.
Michael A CarducciDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Sushant K KachhapDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Channing J PallerDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Janet MendoncaDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Leo Li-Ying ChanDepartment of Technology R&D, Nexcelom Bioscience LLC, Lawrence, MA 01843, United States.
Bo LinDepartment of Technology R&D, Nexcelom Bioscience LLC, Lawrence, MA 01843, United States.
Diane K HartleDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States.
Jeffrey E GreenLaboratory of Cell Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, United States.
Collis A BrownHoward University Cancer Center, Washington DC 20060, United States.
Tamaro S HudsonHoward University Cancer Center, Washington DC 20060, United States.
Howard University · USJohns Hopkins Medicine · USJohns Hopkins University · USFu Jen Catholic University · TWGeorgetown University · USGeorgetown University Medical Center · USNational Cancer Institute · USUniversity of Georgia · USWake Forest University · USWashington DC VA Medical Center · US

Funding

RRD VA IK2 RX001114
6 · The paper itself

Abstract

Previously we demonstrated that muscadine grape skin extract (MSKE), a natural product, significantly inhibited androgen-responsive prostate cancer cell growth by inducing apoptosis through the targeting of survival pathways. However, the therapeutic effect of MSKE on more aggressive androgen-independent prostate cancer remains unknown. This study examined the effects of MSKE treatment in metastatic prostate cancer using complementary PC-3 cells and xenograft model. MSKE significantly inhibited PC-3 human prostate cancer cell tumor growth

Indexed as

Cancer researchCell biologyMolecular biology

Identifiers

PMID30705983
PMCPMC6348279
OpenAlexW2909505041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.