ArticleWorld journal of clinical cases2019
Cardiac involvement in disseminated diffuse large B-cell lymphoma, successful management with chemotherapy dose reduction guided by cardiac imaging: A case report and review of literature.
Article in World journal of clinical cases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Large B-Cell Lymphoma Invading the Heart: Insights From Multimodality Imaging in a Young Woman.JACC. Case reports · 2026Article
- Cardiac mass in a patient with HIV infection: A case report and literature review.Experimental and therapeutic medicine · 2026Article
- HGBL-NOS presenting as widespread extranodal disease without lymphadenopathy: a case report.Frontiers in oncology · 2026Article
- Diffuse myocardial infiltration in secondary cardiac lymphoma: A case report.Oncology letters · 2025Article
- Diffuse Large B Cell Lymphoma Presenting as a Cardiac Mass Complicated by Atrial Arrhythmia.Journal of Brown hospital medicine · 2025Article
- Autopsy case of cardiac mantle cell lymphoma presenting with recurrent pulmonary tumor embolism after chemotherapy.Journal of clinical and experimental hematopathology : JCEH · 2024Article
- Unanticipated Biatrial 18F-Fluorodeoxyglucose (18F-FDG) Uptake in Diffuse Large B-cell Lymphoma Surveillance PET/CT.Cureus · 2024Article
- Scar-Related Monomorphic Ventricular Tachycardia After Treated Right Ventricular Metastatic Diffuse Large B-Cell Lymphoma.JACC. Case reports · 2024Article
- Article
- Echocardiographic Findings of Malignant Lymphoma with Cardiac Involvement: A Single-center Retrospective Observational Study.Internal medicine (Tokyo, Japan) · 2024Observational
- Relapsed/refractory diffuse large B cell lymphoma with cardiac involvement: A case report and literature review.Frontiers in oncology · 2023Article
- Clinical features of cardiac lymphoma: an analysis of 37 cases.The Journal of international medical research · 2021Article
- Secondary Cardiac Lymphoma Presenting as Sick Sinus Syndrome and Atrial Fibrillation Which Required Leadless Pacemaker Implantation.Internal medicine (Tokyo, Japan) · 2021Article
- Surgical treatment of a primary cardiac lymphoma presenting with cardiac tamponade.General thoracic and cardiovascular surgery · 2021Article
- Relationship between chemotherapy-induced adverse reactions and health-related quality of life in patients with breast cancer.Medicine · 2020Observational
- A Rare Case of Atrial Septal Mass Secondary to Lymphoma: Case Report and Review of Literature.Journal of investigative medicine high impact case reportsReview
- Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma.Autopsy & case reportsArticle
- Tumor-Related Pericardial and Myocardial Infiltration in Diffuse Large B-Cell Lymphoma Presenting as an ST-Elevation Myocardial Infarction Mimic: A Case Report.Case reports in oncologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecondary cardiac involvement by lymphoma has received limited attention in the medical literature, despite its grave prognosis. Although chemotherapy improves patients' survival, a subgroup of treated patients dies suddenly due to myocardial rupture following chemotherapy initiation. Reducing the initial chemotherapy dose with dose escalation to standard doses may be effective in minimizing this risk but the data are limited. We report on the successful management of a patient with disseminated diffuse large B-cell lymphoma (DLBCL) involving the heart using such approach. CASE SUMMARY: An 18-year-old male presented to our hospital with six months history of progressive dyspnea, orthopnea and cough. On physical examination, the patient was found to have a plethoric and mildly edematous face, fixed elevation of the right internal jugular vein, suggestive of superior vena cava obstruction, and a pelvic mass. Investigations during admission including a thoracoabdominal computed tomography (CT) scan with CT guided biopsy of the pelvic mass, echocardiography and cardiac magnetic resonance imaging led to the diagnosis of disseminated DLBCL with cardiac involvement. The patients were successfully treated with chemotherapy dose reduction followed by dose escalation to standard doses, under the guidance of cardiac imaging. The patient completed chemotherapy and underwent a successful bone marrow transplant. He is currently in remission and has a normal left ventricular function.
conclusionImaging-guided chemotherapy dosing may minimize the risk of myocardial rupture in cardiac lymphoma. Data are limited. Management should be individualized.
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