Evidence map›Paper›PMID 30705677›Full record

ArticleFrontiers in immunology2018

NKG2A Down-Regulation by Dasatinib Enhances Natural Killer Cytotoxicity and Accelerates Effective Treatment Responses in Patients With Chronic Myeloid Leukemia.

Ming-Chin Chang, Hung-I Cheng, Kate Hsu, Yen-Ning Hsu, Chen-Wei Kao, Yi-Fang Chang, Ken-Hong Lim, Caleb Gonshen Chen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
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  13. Modulation of anti-tumour immunity by XPO1 inhibitors.Exploration of targeted anti-tumor therapy · 2025
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  17. Sustained antiviral response againstFrontiers in pharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ming-Chin ChangDepartment of Hematology, MacKay Memorial Hospital, Taipei, Taiwan.
Hung-I ChengDepartment of Hematology, MacKay Memorial Hospital, Hsin-Chu, Taiwan.
Kate HsuDepartment of Medical Research, Transfusion Medicine & Immunogenetics Laboratories, MacKay Memorial Hospital, Tamsui, Taiwan.
Yen-Ning HsuDepartment of Hematology, MacKay Memorial Hospital, Hsin-Chu, Taiwan.
Chen-Wei KaoGCRC Laboratory, Department of Hematology, MacKay Memorial Hospital, New Taipei, Taiwan.
Yi-Fang ChangDepartment of Hematology, MacKay Memorial Hospital, Taipei, Taiwan.
Ken-Hong LimDepartment of Hematology, MacKay Memorial Hospital, Taipei, Taiwan.
Caleb Gonshen ChenDepartment of Hematology, MacKay Memorial Hospital, Taipei, Taiwan.
Mackay Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of

Indexed as

Cytotoxicity, ImmunologicAdultAgedAged, 80 and overAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBiomarkersCell Line, TumorDasatinibFemaleGene ExpressionGene Expression Regulation, LeukemicHumansImmunophenotypingKiller Cells, NaturalLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAntineoplastic AgentsBiomarkersDasatinibKLRC1 protein, humanNK Cell Lectin-Like Receptor Subfamily Cp38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsBCR-ABLCMLdeep molecular response (DMR)major molecular response (MMR)natural killer cellNKG2Ap38 mitogen-activated protein kinase

Identifiers

PMID30705677
PMCPMC6344416
OpenAlexW2911192406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.