Evidence map›Paper›PMID 30705676›Full record

ReviewFrontiers in immunology2018

Allergen-Specific Antibodies Regulate Secondary Allergen-Specific Immune Responses.

Julia Eckl-Dorna, Sergio Villazala-Merino, Birgit Linhart, Alexander V Karaulov, Yury Zhernov, Musa Khaitov, Verena Niederberger-Leppin, Rudolf Valenta

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05042830 (Contribution of Local Nasal IgE Production to the Boost of Systemic Allergen-specific IgE Production Upon Nasal Allergen Contact - an Explorative Pilot Study), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05042830 narecruitingnot on this mapstarted 2021, after this paper: background citation

Contribution of Local Nasal IgE Production to the Boost of Systemic Allergen-specific IgE Production Upon Nasal Allergen Contact - an Explorative Pilot Study

TypeinterventionalSponsorMedical University of ViennaRan2021 to 2026Enrolled30ConditionsAllergyArmsBlood sampling, Nasal biopsies, Nasal specimen collection, Mucosal RNA sampling, Intranasal challenge
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Single-Domain Antibodies-Novel Tools to Study and Treat Allergies.International journal of molecular sciences · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Optimization ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  18. Review
  19. Plant-based enveloped Ara h 2 bioparticles display exceptional hypo-allergenicity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Julia Eckl-DornaDepartment of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
Sergio Villazala-MerinoDepartment of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
Birgit LinhartDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Alexander V KaraulovLaboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.
Yury ZhernovNRC Institute of Immunology FMBA of Russia, Moscow, Russia.
Musa KhaitovNRC Institute of Immunology FMBA of Russia, Moscow, Russia.
Verena Niederberger-LeppinDepartment of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
Rudolf ValentaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATInstitute of Immunology and Physiology · RUSechenov University · RU

Funding

Austrian Science Fund FWF F 4605
6 · The paper itself

Abstract

Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensensitivity disease. It is based on the production of IgE antibodies and T cell responses against

Indexed as

ImmunityAllergensAnimalsAntibodiesAntibodies, BlockingAntibody SpecificityAntigen PresentationAntigen-Presenting CellsB-LymphocytesDesensitization, ImmunologicEpitopesHumansHypersensitivityImmunoglobulin EImmunologic MemoryLymphocyte ActivationAllergensAntibodiesAntibodies, BlockingEpitopesImmunoglobulin Eallergenallergen-specific immunotherapyallergyantibodyfacilitated allergen presentation (FAP)IgE+ memory B cellsuper-crosslinkingT cell response

Identifiers

PMID30705676
PMCPMC6344431
OpenAlexW2905535936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.