ArticleFrontiers in microbiology2018
Structural and Phylogenetic Diversity of Anaerobic Carbon-Monoxide Dehydrogenases.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 68 citations in OpenAlex.
- Beyond Canonical CO Oxidation: Structural and Evolutionary Insights Into a Non-Canonical Carbon Monoxide Dehydrogenase.Angewandte Chemie (International ed. in English) · 2026Article
- Draft genome sequence of a novel hydrogenogenic CO-oxidizing bacterium that is phylogenetically closely related to the family Thermicanaceae.Microbiology resource announcements · 2026Article
- Entangled hydrophobic and hydrophilic networks in carbon monoxide dehydrogenase.Chemical science · 2026Article
- Genomic Survey of Carbon Monoxide Dehydrogenases Reveals Their Widespread Distribution in Marine Habitats.Environmental microbiology reports · 2026Article
- Carbon monoxide metabolism in freshwater anaerobic methanotrophic archaea.Nature communications · 2026Article
- Carbon monoxide oxidation expands the known metabolic capacity in anaerobic methanotrophic consortia.Nature communications · 2026Article
- Article
- Comparative Physiology and Genomics of Thermincola and Carboxydocella Strains and Description of Two Novel Isolates.Environmental microbiology · 2026Article
- Carboxydotrophic Acetogenesis in Alkaline Conditions Results in Transient Formate Production by the Halo-Alkaliphilic Acetogen Haloacetibacter carboxydivorans Gen. Nov. sp. Nov.Environmental microbiology reports · 2026Article
- Carbon monoxide-driven proton respiration enables facultative anaerobes to survive electron acceptor limitation.The ISME journal · 2026Article
- Hydrogen excess drives metabolic reprogramming and viral dynamics in syngas-converting microbiomes.Environmental science and ecotechnology · 2025Article
- In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of Nitrate on Hydrogenogenic Carbon Monoxide Oxidation in Parageobacillus thermoglucosidasius.Environmental microbiology reports · 2025Article
- Nickel model complexes to mimic carbon monoxide dehydrogenase reactions.Chemical science · 2025Review
- Article
- Metabolism of CO and H2 by pioneer bacteria in volcanic soils and the phyllosphere.The ISME journal · 2025Review
- Molecular evolution of the Wood-Ljungdahl pathway and the reductive glycine pathway inFrontiers in microbiology · 2025Article
- Phylogenetic diversity of putative nickel-containing carbon monoxide dehydrogenase-encoding prokaryotes in the human gut microbiome.Microbial genomics · 2024Article
- Article
- Nickel-organo compounds as potential enzyme precursors under simulated early Earth conditions.Communications chemistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaerobic Ni-containing carbon-monoxide dehydrogenases (Ni-CODHs) catalyze the reversible conversion between carbon monoxide and carbon dioxide as multi-enzyme complexes responsible for carbon fixation and energy conservation in anaerobic microbes. However, few biochemically characterized model enzymes exist, with most Ni-CODHs remaining functionally unknown. Here, we performed phylogenetic and structure-based Ni-CODH classification using an expanded dataset comprised of 1942 non-redundant Ni-CODHs from 1375 Ni-CODH-encoding genomes across 36 phyla. Ni-CODHs were divided into seven clades, including a novel clade. Further classification into 24 structural groups based on sequence analysis combined with structural prediction revealed diverse structural motifs for metal cluster formation and catalysis, including novel structural motifs potentially capable of forming metal clusters or binding metal ions, indicating Ni-CODH diversity and plasticity. Phylogenetic analysis illustrated that the metal clusters responsible for intermolecular electron transfer were drastically altered during evolution. Additionally, we identified novel putative Ni-CODH-associated proteins from genomic contexts other than the Wood-Ljungdahl pathway and energy converting hydrogenase system proteins. Network analysis among the structural groups of Ni-CODHs, their associated proteins and taxonomies revealed previously unrecognized gene clusters for Ni-CODHs, including uncharacterized structural groups with putative metal transporters, oxidoreductases, or transcription factors. These results suggested diversification of Ni-CODH structures adapting to their associated proteins across microbial genomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.