ArticleFrontiers in neurology2018
Spinal Hyper-Excitability and Altered Muscle Structure Contribute to Muscle Hypertonia in Newborns After Antenatal Hypoxia-Ischemia in a Rabbit Cerebral Palsy Model.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- Multimodal MRI of white matter development and selective motor control in preterm infants.NeuroImage. Clinical · 2026Article
- Effect of continuous Ia fibre activity suppression on hyperreflexia-related spasticity and maladaptive synaptic connections in the spinal cord after injury.Scientific reports · 2025Article
- A low-cost, open-source device to evaluate limb stiffness in a rabbit model of cerebral palsy.Frontiers in bioengineering and biotechnology · 2025Article
- Rate-Dependent Depression of the Hoffmann Reflex: Practical Applications in Painful Diabetic Neuropathy.Diabetes & metabolism journal · 2024Review
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.The Journal of physiology · 2023Article
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.bioRxiv : the preprint server for biology · 2023Article
- Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy.Journal of neuroscience research · 2022Article
- "The First Thousand Days" Define a Fetal/Neonatal Neurology Program.Frontiers in pediatrics · 2021Review
- Altered Motoneuron Properties Contribute to Motor Deficits in a Rabbit Hypoxia-Ischemia Model of Cerebral Palsy.Frontiers in cellular neuroscience · 2020Article
- Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy.Journal of neurophysiology · 2019Article
- Transdisciplinary fetal-neonatal neurology training integrates women's and children's health with life-course brain capital strategies: a narrative review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Rabbit kits after global antenatal hypoxic-ischemic injury exhibit motor deficits similar to humans with cerebral palsy. We tested several mechanisms previously implicated in spinal hyper-excitability after perinatal brain injury that may explain muscle hypertonia in newborns. Stiffness of hind limb muscles during passive stretch, electromyogram, and spinal excitability by Hoffman reflex, were assessed in rabbit kits with muscle hypertonia after global hypoxic-ischemic brain injury and naïve controls. Affected muscle architecture, motoneuron morphology, primary afferents density, gliosis, and KCC2 expression transporter in the spinal cord were also examined. Decrease knee stiffness after anesthetic administration was larger, but residual stiffness was higher in hypertonic kits compared to controls. Hypertonic kits exhibited muscle shortening and atrophy, in both agonists and antagonists. Sarcomere length was longer in tibialis anterior in hypertonic kits than in controls. Hypertonic kits had decreased rate dependent depression and increased H
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