ArticleFrontiers in psychiatry2018
EEG 40 Hz Coherence Decreases in REM Sleep and Ketamine Model of Psychosis.
Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 28 citations in OpenAlex.
- Decoupling of cortical activity from behavioral state following administration of the classic psychedelic DOI.Neuropharmacology · 2024Article
- Effects of gender and age on sleep EEG functional connectivity differences in subjects with mild difficulty falling asleep.Frontiers in psychiatry · 2024Article
- Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex.eLife · 2023Article
- Pedunculopontine-induced cortical decoupling as the neurophysiological locus of dissociation.Psychological review · 2023Article
- Delirium detection using GAMMA wave and machine learning: A pilot study.Research in nursing & health · 2022Article
- Ketamine and sleep modulate neural complexity dynamics in cats.The European journal of neuroscience · 2022Article
- The Impact of Sleep on Neurocognition and Functioning in Schizophrenia-Is It Time to Wake-Up?Journal of psychiatry and brain science · 2022Article
- Understanding the neurological mechanism involved in enhanced memory recall task following binaural beat: a pilot study.Experimental brain research · 2021Article
- A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms.PLoS computational biology · 2021Article
- Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.Cell reports · 2021Article
- EEG Gamma Band Alterations and REM-like Traits Underpin the Acute Effect of the Atypical Psychedelic Ibogaine in the Rat.ACS pharmacology & translational science · 2021Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Cognitive processes are carried out during wakefulness by means of extensive interactions between cortical and subcortical areas. In psychiatric conditions, such as psychosis, these processes are altered. Interestingly, REM sleep where most dreams occurs, shares electrophysiological, pharmacological, and neurochemical features with psychosis. Because of this fact, REM sleep is considered a natural model of psychosis. Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist that at sub-anesthetic dose induces psychotomimetic-like effects in humans and animals, and is employed as a pharmacological model of psychosis. Oscillations in the gamma frequency band of the electroencephalogram (EEG), mainly at about 40 Hz, have been involved in cognitive functions. Hence, the present study was conducted to analyze the EEG low gamma (30-45 Hz) band power and coherence of the cat, in natural (REM sleep) and pharmacological (sub-anesthetic doses of ketamine) models of psychosis. These results were compared with the gamma activity during alert (AW) and quiet wakefulness (QW), as well as during non-REM (NREM) sleep. Five cats were chronically prepared for polysomnographic recordings, with electrodes in different cortical areas. Basal recordings were obtained and ketamine (5, 10, and 15 mg/kg, i.m.) was administrated. Gamma activity (power and coherence) was analyzed in the abovementioned conditions. Compared to wakefulness and NREM sleep, following ketamine administration gamma coherence decreased among all cortical regions studied; the same coherence profile was observed during REM sleep. On the contrary, gamma power was relatively high under ketamine, and similar to QW and REM sleep. We conclude that functional interactions between cortical areas in the gamma frequency band decrease in both experimental models of psychosis. This uncoupling of gamma frequency activity may be involved in the cognitive features shared by dreaming and psychosis.
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