ArticleFrontiers in molecular neuroscience2018
EZH2 Influences mdDA Neuronal Differentiation, Maintenance and Survival.
Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Review
- Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons.Handbook of behavioral neuroscience · 2025Article
- Involvement of histone methylation in the regulation of neuronal death.Journal of physiology and biochemistry · 2023Review
- PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons.Science advances · 2022Article
- Silencing the enhancer of zeste homologue 2,Neural regeneration research · 2022Article
- Brain metastases: It takes two factors for a primary cancer to metastasize to brain.Frontiers in oncology · 2022Article
- Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids.Nature communications · 2021Article
- Adolescent oxycodone exposure inhibits withdrawal-induced expression of genes associated with the dopamine transmission.Addiction biology · 2021Article
- The role and mechanisms of polycomb repressive complex 2 on the regulation of osteogenic and neurogenic differentiation of stem cells.Cell proliferation · 2021Review
- Acquisition of the Midbrain Dopaminergic Neuronal Identity.International journal of molecular sciences · 2020Review
- Chemical Genetics Screen Identifies Epigenetic Mechanisms Involved in Dopaminergic and Noradrenergic Neurogenesis in Zebrafish.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last decade several components have been identified to be differentially expressed in subsets of mesodiencephalic dopaminergic (mdDA) neurons. These differences in molecular profile have been implied to be involved in the selective degeneration of the SNc neurons in Parkinson's disease. The emergence and maintenance of individual subsets is dependent on different transcriptional programs already present during development. In addition to the influence of transcription factors, recent studies have led to the hypothesis that modifications of histones might also influence the developmental program of neurons. In this study we focus on the histone methyltransferase EZH2 and its role in the development and maintenance of mdDA neurons. We generated two different conditional knock out (cKO) mice; an
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