ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2019
Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Serum Uric Acid Is Associated with Insulin Resistance in Non-Diabetic Subjects.Journal of clinical medicine · 2025Article
- Association Between Circulating Fatty Acids and Blood Pressure: A Review.Current nutrition reports · 2025Review
- Association between cardiometabolic index and hepatic steatosis and liver fibrosis: a population-based study.Hormones (Athens, Greece) · 2024Article
- Article
- Review
- Effect of physical activity on free fatty acids, insulin resistance, and blood pressure in obese older women.Physical activity and nutrition · 2024Article
- Tea seed saponin‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells.Molecular medicine reports · 2024Article
- Multi-omics microsampling for the profiling of lifestyle-associated changes in health.Nature biomedical engineering · 2024Article
- Pancreatic GLUT2 protein expression and isolated islets insulin secretion decreased in high-fat fed rat dams.Journal of diabetes and metabolic disorders · 2023Article
- Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.Metabolites · 2023Review
- A Glimpse into Milestones of Insulin Resistance and an Updated Review of Its Management.Nutrients · 2023Review
- Sex-Specific Contribution of Cardiometabolic Index in Predicting Metabolic Dysfunction-Associated Fatty Liver Disease: Insights from a General Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- The cause-effect relation of tuberculosis on incidence of diabetes mellitus.Frontiers in cellular and infection microbiology · 2023Review
- Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome.Renal failure · 2022Article
- Sex-specific contribution of lipid accumulation product and cardiometabolic index in the identification of nonalcoholic fatty liver disease among Chinese adults.Lipids in health and disease · 2022Article
- Energy metabolism in skeletal muscle cells from donors with different body mass index.Frontiers in physiology · 2022Article
- Distinct Dose-Dependent Association of Free Fatty Acids with Diabetes Development in Nonalcoholic Fatty Liver Disease Patients.Diabetes & metabolism journal · 2021Article
- Review
- Article
- Metabolomic signatures for visceral adiposity and dysglycaemia in Asian Chinese and Caucasian European adults: the cross-sectional TOFI_Asia study.Nutrition & metabolism · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFree fatty acids (FFAs) are associated with insulin secretion and insulin resistance. However, the associations among FFAs, obesity, and progression from a normal to a prediabetic state are unclear.
methodsNondiabetic subjects (5,952) were divided in two groups according to their body mass index (BMI): obese subjects (BMI ≥24 kg/m
resultsA U-shaped relationship between FFAs and HOMA-IR was observed. After adjusting for potential confounders, the turning points of FFA levels in the curves were 0.54 mmol/L in the nonobese group and 0.61 mmol/L in the obese group. HOMA-IR levels decreased with increasing FFA concentrations before the turning points (regression coefficient [β]= - 0.9,
conclusionFFA levels were associated with insulin resistance in nondiabetic subjects, and HOMA-IR in nonobese individuals was more sensitive to FFA changes. Monitoring and controlling plasma FFA levels in obese subjects is significant in decreasing insulin resistance and preventing diabetes.
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