Evidence map›Paper›PMID 30705541›Full record

ArticleJournal of clinical orthopaedics and trauma

Quadriceps muscle characteristics and subcutaneous fat assessed by ultrasound and relationship with function in patients with knee osteoarthritis awaiting knee arthroplasty.

M Núñez, E Nuñez, J M Moreno, V Segura, L Lozano, N M Maurits, J M Segur, S Sastre

Registry-linked trialAbstract read
In one paragraph

Article in Journal of clinical orthopaedics and trauma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05348590 (Nutritional Assessment Project In Surgical Patients Focused On Body Composition And Functionality), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05348590 unknown statusnot on this map

Nutritional Assessment Project In Surgical Patients Focused On Body Composition And Functionality

Typeobservational_patient_registrySponsorUniversidad de ZaragozaRan2023 to 2025Enrolled1,000ConditionsSurgery, Nutrition Disorders
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Possible Sex Differences in the Morphological and Functional Muscle Quality Reflected by Phase Angle: Implications for Muscle Quality Assessment.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
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  3. Article
  4. Review
  5. Article
  6. Article
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  8. Reliability of point-of-care ultrasound for measuring quadriceps femoris muscle thickness.European journal of physical and rehabilitation medicine · 2022
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M NúñezRheumatology Department, RESPAL Group and Biomedical Research Institute 6 August Pi i Sunyer (IDIBAPS), Hospital Clínic Universitari, Villarroel, 170, 08036 Barcelona, Catalonia.
E NuñezSAP Support al Diagnòstic i al Tractament, RESPAL Group and Institut Català de la 8 Salut. Avda. Drassanes, 17-21, 08001 Barcelona, Spain.
J M MorenoTechnical University of Catalunya (UPC) Department of Electronic Engineering Advanced Hardware Architectures Group. Campus Nord,Building C4 c/Jordi Girona 1-3 0.08034 Barcelona, Spain.
V SeguraTechnical University of Catalunya (UPC) Department of Electronic Engineering Advanced Hardware Architectures Group. Campus Nord,Building C4 c/Jordi Girona 1-3 0.08034 Barcelona, Spain.
L LozanoOrthopedic Surgery Department, RESPAL Group and Biomedical Research Institute 15 August Pi i Sunyer (IDIBAPS), Hospital Clínic Universitari, Villarroel, 170, 08036 Barcelona, Catalonia.
N M MauritsDepartment of Neurology, University Medical Center Groningen, University of Groningen. Hanzeplein 1 9713 GZ Groningen, The Netherlands.
J M SegurOrthopedic Surgery Department, RESPAL Group and Biomedical Research Institute 15 August Pi i Sunyer (IDIBAPS), Hospital Clínic Universitari, Villarroel, 170, 08036 Barcelona, Catalonia.
S SastreOrthopedic Surgery Department, RESPAL Group and Biomedical Research Institute 15 August Pi i Sunyer (IDIBAPS), Hospital Clínic Universitari, Villarroel, 170, 08036 Barcelona, Catalonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with severe knee osteoarthritis are evaluated for total knee replacement (TKR), whose main indications are persistent pain and severe functional limitations substantially affecting mobility. However, evaluation of pain intensity and functional disability is difficult to standardize.

objectiveTo evaluate the relationship between quadriceps muscle thickness (QMT) and quality; the QMT and subcutaneous fat thickness (SFT) and QMT and function in patients with knee OA on a waiting list for TKR.

methodsCross-sectional study in consecutively-enrolled patients. Variables: SFT, QMT and rectus femoris muscle quality, assessed by echointensity (EI). Function by the Timed Up & Go Test (TUG); sociodemographic and clinical variables and physical activity were determined. Karl Pearson correlations and multiple linear regression were used.

results61 patients (45 female, mean age 69.7 years [SD 7.2], mean BMI 33.0 [SD 5.7], mean comorbidities 3.3 [SD 2.0], 52.5% regular physical activity) were studied. Mean TUG was 15.1 (SD 6.1). Variables retained in the regression model explained 36% of variability in the TUG. Greater muscle content (percentage) (r = -0,291) was associated with better TUG scores (p = 0.001). Greater muscle EI was negatively (r = -0,364) associated with function (p = 0.006). Older age was associated with worse TUG scores while regular physical activity was associated with better TUG scores (p = 0.001 and p = 0.008, respectively).

conclusionsA higher percentage of quadriceps muscle and better muscle quality (lower EI) was associated with better function. Age and exercise levels influenced function. Ultrasound may provide.

Indexed as

Knee osteoarthritisMuscle ecographyMuscularTKR

Identifiers

PMID30705541
PMCPMC6349663

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.