ArticlePteridines2018
Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health.
Article in Pteridines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Anti-inflammatory diets and mental health: a scoping review of randomized controlled trials and systematic evidence syntheses.Frontiers in nutrition · 2026Pooled it
- Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Periodontitis in obese adults with and without metabolic syndrome: a cross-sectional study.BMC oral health · 2023Trial
- Oral Health Status and Cardinal Symptoms of Depression in the Old Order Amish: a cross-sectional study.Research square · 2026Article
- Comparison of caregiver-performed toothbrushing with triple- and single-headed toothbrushes in preschool children with developmental disabilities: a randomized crossover study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- The association between oral health and cardiovascular disease risk and the potential mediating role of depressive symptoms: evidence from the English longitudinal study of ageing.BMC oral health · 2026Article
- Article
- Evidence-Based Laboratory Medicine for Cardiovascular Disease Management in Mental Healthcare: A Literature Review.Cureus · 2026Review
- Oral Dysbiosis and Neuroinflammation: Implications for Alzheimer's, Parkinson's and Mood Disorders.Microorganisms · 2026Review
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- Association between weight-adjusted waist index and severe periodontitis using NHANES 2009-2014.Scientific reports · 2025Article
- Periodontal Disease in Saudi Arabia: A Systematic Review of Prevalence and Associated Risk Factors.Diagnostics (Basel, Switzerland) · 2025Review
- Bidirectional interplay between periodontal disease and carotid artery disease: a comprehensive holistic review.Frontiers in cellular and infection microbiology · 2025Review
- Association Between Geriatric Oral Health Assessment Index and Cardiovascular Disease in Korean Older Adults.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Article
- A pathological convergence theory for non-communicable diseases.Aging medicine (Milton (N.S.W)) · 2023Review
- Biochemical and Microbiological Aspects of the Oral Cavity of Children and Young People with Neurological Impairment and Oropharyngeal Dysphagia.Life (Basel, Switzerland) · 2023Article
- Origin of Sex-Biased Mental Disorders: Do Males and Females Experience Different Selective Regimes?Journal of molecular evolution · 2022Article
- Impact of Intermittent Fasting on Metabolic Syndrome and Periodontal Disease-A Suggested Preventive Strategy to Reduce the Public Health Burden.International journal of environmental research and public health · 2022Review
- Prevalence and Quality of Endodontic Treatment in Patients with Cardiovascular Disease and Associated Risk Factors.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.