ArticleMolecular psychiatry2020
SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex.
Open access · hybridAbstract read
In one paragraph
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications.Molecular psychiatry · 2026Pooled it
- Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in posttraumatic stress mouse model.The Journal of clinical investigation · 2026Article
- Good vibes keep worries at bay: a prefrontal-hypothalamic pathway engages positive affect to mitigate fear.The Journal of clinical investigation · 2026Article
- Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes.Molecular psychiatry · 2026Article
- Review
- Network Pharmacology Reveals the Potential Mechanism of Ketamine in Improving Cognitive Impairment in Patients With Depression.Alpha psychiatry · 2026Article
- IL-17A in the hippocampus regulates despair-like behaviors via inhibitory synaptic transmission.Acta pharmacologica Sinica · 2026Article
- Enhanced Therapeutic Effects of Extracellular Vesicles Targeting MiR-137 Contribute to Functional Recovery by Attenuating Neuronal Injury After Ischemic Stroke.Neuroscience bulletin · 2026Article
- [Esketamine alleviates depression-like behaviors in mice with chronic restraint stress by activating glutamatergic neurons in the medial prefrontal cortex].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- From energy metabolism to mood regulation: The rise of lactate as a therapeutic target.Journal of advanced research · 2026Review
- Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis.Developmental cell · 2026Article
- Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer's disease.Molecular psychiatry · 2025Article
- Astrocytic dopamine D1 receptor modulates glutamatergic transmission and synaptic plasticity in the prefrontal cortex through d-serine.Acta pharmaceutica Sinica. B · 2025Article
- Molecular Links Between Metabolism and Mental Health: Integrative Pathways from GDF15-Mediated Stress Signaling to Brain Energy Homeostasis.International journal of molecular sciences · 2025Review
- Oral olsalazine/ellagic acid/ZnClMaterials today. Bio · 2025Article
- SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling.Scientific reports · 2025Article
- Mito-TEMPO Mitigates Fibromyalgia Induced by Reserpine in Rats: Orchestration Between SIRT1, Mitochondrial Dynamics, Endoplasmic Reticulum and miRNA-320.Neurochemical research · 2025Article
- The Role of Mitochondrial Energy Metabolism in the Mechanism of Exercise Improving Depression.Current issues in molecular biology · 2025Review
- Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression-Related Behaviors by Urolithin B via the SIRT1-FOXO1 Pathway.CNS neuroscience & therapeutics · 2025Article
- Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review).Biomedical reports · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Yun LeiDepartment of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Jiangong WangDepartment of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Dan WangInstitute for Metabolic & Neuropsychiatric Disorders, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Chen LiDepartment of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Bin LiuDepartment of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Xing FangDepartment of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Jingjing YouDepartment of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Ming GuoInstitute for Metabolic & Neuropsychiatric Disorders, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Xin-Yun LuDepartment of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA. xylu@augusta.edu.
The University of Texas Health Science Center at San Antonio · USBinzhou University · CNAugusta University · USBinzhou Medical University · CN
Funding
The Adipocyte PPARgama/Adiponectin Axis and Alzheimer's DiseaseRF1AG062166 · NIA · AUGUSTA UNIVERSITY · PI LU, XIN-YUN · 2019 to 2019
$3.5MCharacterization of leptin's antidepressant activityR01MH076929 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LU, XIN-YUN · 2007 to 2016
$3.3MAdiponectin signaling in mood regulationR01MH100583 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LU, XIN-YUN · 2013 to 2017
$1.9MAdiponectin regulation of the mesolimbic dopamine systemR21MH096251 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LODGE, DANIEL, LU, XIN-YUN · 2012 to 2013
$399kNIA NIH HHS RF1 AG062166NIMH NIH HHS R01 MH076929NIMH NIH HHS R01 MH100583NIMH NIH HHS R21 MH096251U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH076929U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH096251U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH100583
Abstract
Sirtuin 1 (SIRT1), an NAD
Indexed as
Sex CharacteristicsSynaptic TransmissionAnimalsDepressionExcitatory Postsynaptic PotentialsFemaleMajor Depressive DisorderMaleMiceMice, Inbred C57BLNeuronsPrefrontal CortexPyramidal CellsSirtuin 1Sirt1 protein, mouseSirtuin 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.