ArticleScientific reports2019
Antibody-free digital influenza virus counting based on neuraminidase activity.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Chemical basis of fluorogenic substrate probe design: revisiting the past to discover the new in biochemistry.RSC chemical biology · 2026Review
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- Fibronectin in the olfactory mucus increases sensitivity of olfactory receptor response to odorants.Science advances · 2025Article
- In vitro one-pot construction of influenza viral genomes for virus particle synthesis based on reverse genetics system.PloS one · 2024Article
- Digital Cascade Assays for ADP- or ATP-Producing Enzymes Using a Femtoliter Reactor Array Device.ACS sensors · 2023Article
- Improvement of Sensitivity and Speed of Virus Sensing Technologies Using nm- and μm-Scale Components.Sensors (Basel, Switzerland) · 2023Review
- Quantitative performance of digital ELISA for the highly sensitive quantification of viral proteins and influenza virus.Analytical and bioanalytical chemistry · 2023Article
- Elucidation and control of low and high active populations of alkaline phosphatase molecules for quantitative digital bioassay.Protein science : a publication of the Protein Society · 2021Article
- Avidin-biotin complex-based capture coating platform for universal Influenza virus immobilization and characterization.PloS one · 2021Article
- Visualizable detection of nanoscale objects using anti-symmetric excitation and non-resonance amplification.Nature communications · 2020Article
- Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples.Science advances · 2020Article
- Rapid functionalisation and detection of viruses via a novel CaScientific reports · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is large demand for a quantitative method for rapid and ultra-sensitive detection of the influenza virus. Here, we established a digital influenza virus counting (DIViC) method that can detect a single virion without antibody. In the assay, a virion is stochastically entrapped inside a femtoliter reactor array device for the fluorogenic assay of neuraminidase, and incubated for minutes. By analyzing 600,000 reactors, the practical limit of detection reached the order of 10
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