ArticleScientific reports2019
Small changes in synaptic gain lead to seizure-like activity in neuronal network at criticality.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Redox modulation of the complement cascade contributes to synapse loss in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Neuronal hyperactivity in neurons derived from individuals with gray matter heterotopia.Nature communications · 2025Article
- Dravet syndrome: novel insights intoFrontiers in neuroscience · 2025Review
- Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies.Ageing research reviews · 2024Review
- Psychedelics and disorders of consciousness: the current landscape and the path forward.Neuroscience of consciousness · 2024Article
- Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression.Frontiers in synaptic neuroscience · 2023Review
- Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models.Frontiers in neurology · 2023Review
- Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model.iScience · 2022Article
- Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation.Frontiers in computational neuroscience · 2021Review
- Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study.The Journal of general physiology · 2020Article
- Persistent sodium current blockers can suppress seizures caused by loss of low-threshold D-type potassium currents: Predictions from an in silico study of KEpilepsia open · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a neurological disorder characterised by spontaneous recurrent seizures. The mechanisms by which multiple molecular and cellular changes lead to seizures is not well understood. Here, we study cortical seizure generation by simulating the activity of neuron groups in a network using the laminar cortex model. We identified a clear boundary between low-amplitude, asynchronous activity and high-amplitude, rhythmic activity, around which small changes in excitatory synaptic gain led to strong oscillatory activity. Neuron groups only responded significantly to stimulation around the boundary. The consequences of biophysical changes induced by epilepsy-related SCN1A mutations were also examined. Marked reduction in neuronal inhibition, as caused by mutations underlying Dravet syndrome, invariably led to strong neuronal firing, whereas small reductions in inhibition could cause significant changes when the network was poised close to the boundary. The study highlights the critical role of network dynamics in seizure genesis.
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