Evidence map›Paper›PMID 30705337›Full record

Trial reportScientific reports2019

Cardiovascular risk algorithms in primary care: Results from the DETECT study.

Tanja B Grammer, Alexander Dressel, Ingrid Gergei, Marcus E Kleber, Ulrich Laufs, Hubert Scharnagl, Uwe Nixdorff, Jens Klotsche, Lars Pieper, David Pittrow and 3 more

Erratum issuedOpen access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
8.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Statins for primary prevention of cardiovascular disease in Germany: benefits and costs.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 2 countries.

Tanja B GrammerUniversity of Heidelberg, Mannheim Medical Faculty, Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim, Germany. tanja.grammer@medma.uni-heidelberg.de.
Alexander DresselUniversity of Heidelberg, Mannheim Medical Faculty, Department of Internal Medicine V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Mannheim, Germany.
Ingrid GergeiUniversity of Heidelberg, Mannheim Medical Faculty, Department of Internal Medicine V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Mannheim, Germany.
Marcus E KleberUniversity of Heidelberg, Mannheim Medical Faculty, Department of Internal Medicine V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Mannheim, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Ulrich LaufsClinic and Polyclinic of Cardiology, University Clinic Leipzig, Leipzig, Germany.
Hubert ScharnaglMedical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria.
Uwe NixdorffEuropean Prevention Center, EPC GmbH, Düsseldorf, Germany. nixdorff@epccheckup.de.
Jens KlotscheGerman Research Center of Rheumatology Berlin, Leibnitz Institute, Berlin, Germany.
Lars PieperCharité Universitätsmedizin Berlin, Institute of Social Medicine, Epidemiology and Health Economics, Berlin, Germany.
David PittrowTechnical University Dresden, Medical Faculty, Institute of Clinical Pharmacology, Dresden, Germany.
Sigmund SilberCardiology Outpatient Clinic Tal, Munich, Germany.
Hans-Ulrich WittchenTechnical University Dresden, Institute of Clinical Psychology and Psychotherapy, Dresden, Germany.
Winfried MärzUniversity of Heidelberg, Mannheim Medical Faculty, Department of Internal Medicine V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Mannheim, Germany.
Heidelberg University · DEMedical University of Graz · ATBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEEuropean Patent Organisation · DEGerman Rheumatism Research Centre · DEMax Planck Institute of Psychiatry · DEOphthalmology Clinic · DETechnische Universität Dresden · DEUniversity Hospital Leipzig · DEUniversity of Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. The risk equations correlate well with each other. All risk equations have a similar discriminatory power. Absolute risks differ widely, in part due to the components of clinical endpoints predicted: The risk equations produced median risks between 8.4% and 2.0%. With three out of 10 risk scores calculated and observed risks well coincided. At a risk threshold of 10 percent in 10 years, the ACC/AHA atherosclerotic cardiovascular disease (ASCVD) equation has a sensitivity to identify future CVD events of approximately 80%, with the highest specificity (69%) and positive predictive value (17%) among all the equations. Due to the most precise calibration over a wide range of risks, the large age range covered and the combined endpoint including non-fatal and fatal events, the ASCVD equation provides valid risk prediction for primary prevention in Germany.

Indexed as

AlgorithmsPrimary Health CareAdultAgedAtherosclerosisFemaleGermanyHumansMaleMiddle AgedProspective StudiesRisk Assessment

Identifiers

PMID30705337
PMCPMC6355969
OpenAlexW2911745473

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.