ArticleNature communications2019
Modular Design of Programmable Mechanofluorescent DNA Hydrogels.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Programmable DNA protonuclei reveal environmental context on protein phase separation.Nature communications · 2026Article
- Systematic Exploration of Synthesis and Function Landscapes for DNA Hydrogels.ACS synthetic biology · 2026Article
- Decoupling Dynamics and Crosslink Stability in Supramolecular Hydrogels Using Associative Exchange.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Carbon Dot-Based Mechanofluorescent Hydrogel with Tunable Fluorescence for Bioengineering Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- DNA-based hydrogels: Ideal biomaterials for cartilage organoids.Fundamental research · 2025Review
- Advances in programmable DNA nanostructures enabling stimuli-responsive drug delivery and multimodal biosensing.RSC chemical biology · 2025Review
- Review
- Nuclease-Resistant L-DNA Tension Probes Enable Long-Term Force Mapping of Single Cells and Cell Consortia.Angewandte Chemie (International ed. in English) · 2024Article
- De novo DNA-based catch bonds.Nature chemistry · 2024Article
- Micromechanical Indentation Platform for Rapid Analysis of Viscoelastic Biomolecular Hydrogels.Small methods · 2024Article
- DNA-empowered synthetic cells as minimalistic life forms.Nature reviews. Chemistry · 2024Review
- Autonomous assembly and disassembly of gliding molecular robots regulated by a DNA-based molecular controller.Science advances · 2024Article
- Mechanically Active Supramolecular Systems.Small science · 2024Article
- Bimodal DNA self-origami material with nucleic acid function enhancement.Journal of nanobiotechnology · 2024Article
- Review
- Bioinspired Multistimuli-Induced Synergistic Changes in Color and Shape of Hydrogel and Actuator Based on Fluorescent Microgels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Programmable all-DNA hydrogels based on rolling circle and multiprimed chain amplification products.APL bioengineering · 2023Article
- Dynamic matrices with DNA-encoded viscoelasticity for cell and organoid culture.Nature nanotechnology · 2023Article
- Force-Triggered Self-Destructive Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- DNA droplets for intelligent and dynamical artificial cells: from the viewpoint of computation and non-equilibrium systems.Interface focus · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanosensing systems are ubiquitous in nature and control many functions from cell spreading to wound healing. Biologic systems typically rely on supramolecular transformations and secondary reporter systems to sense weak forces. By contrast, synthetic mechanosensitive materials often use covalent transformations of chromophores, serving both as force sensor and reporter, which hinders orthogonal engineering of their sensitivity, response and modularity. Here, we introduce FRET-based, rationally tunable DNA tension probes into macroscopic 3D all-DNA hydrogels to prepare mechanofluorescent materials with programmable sacrificial bonds and stress relaxation. This design addresses current limitations of mechanochromic system by offering spatiotemporal resolution, as well as quantitative and modular force sensing in soft hydrogels. The programmable force probe design further grants temporal control over the recovery of the mechanofluorescence during stress relaxation, enabling reversible and irreversible strain sensing. We show proof-of-concept applications to study strain fields in composites and to visualize freezing-induced strain patterns in homogeneous hydrogels.
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