Evidence map›Paper›PMID 30705258›Full record

ArticleTranslational psychiatry2019

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations.

Janine Diehl-Schmid, Abigail Licata, Oliver Goldhardt, Hans Förstl, Igor Yakushew, Markus Otto, Sarah Anderl-Straub, Ambros Beer, Albert Christian Ludolph, Georg Bernhard Landwehrmeyer and 16 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The genome ofMicrobiology resource announcements · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Frontotemporal Dementia and Glucose Metabolism.Frontiers in neuroscience · 2022
    Review
  16. Review
  17. Article
  18. Cognitive dysfunction in amyotrophic lateral sclerosis: can we predict it?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 13 institutions in 1 country.

Janine Diehl-SchmidDepartment of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. janine.diehl-schmid@tum.de.
Abigail LicataDepartment of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Oliver GoldhardtDepartment of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Hans FörstlDepartment of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Igor YakushewDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Markus OttoDepartment of Neurology, Ulm University Hospital, Ulm, Germany.
Sarah Anderl-StraubDepartment of Neurology, Ulm University Hospital, Ulm, Germany.
Ambros BeerDepartment of Neurology, Ulm University Hospital, Ulm, Germany.
Albert Christian LudolphDepartment of Neurology, Ulm University Hospital, Ulm, Germany.
Georg Bernhard LandwehrmeyerDepartment of Neurology, Ulm University Hospital, Ulm, Germany.
Johannes LevinNeurologische Klinik, Ludwig-Maximilians-Universität München, Munich, Germany.
Adrian DanekNeurologische Klinik, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID http://orcid.org/0000-0001-8857-5383
Klaus FliessbachDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Annika SpottkeGerman Center for Neurodegenerative Diseases (DZNE), Site Bonn, Bonn, Germany.
Klaus FassbenderDepartment of Neurology, Saarland University, Homburg/Saar, Germany.
Epameinondas LyrosDepartment of Neurology, Saarland University, Homburg/Saar, Germany.
Johannes PrudloDepartment of Neurology, Rostock University Medical Center, Rostock, Germany.
Bernd Joachim KrauseDepartment of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany.
Alexander VolkInstitute of Human Genetics, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Dieter EdbauerGerman Center for Neurodegenerative Diseases (DZNE), Site Munich, Munich, Germany.
Matthias Leopold SchroeterClinic for Cognitive Neurology, University Clinic Leipzig, Leipzig, Germany.
Alexander DrzezgaDepartment of Nuclear Medicine, University of Cologne, Cologne, Germany.
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Martin LauerDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
FTLDc Study Group
Timo GrimmerDepartment of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
TUM Klinikum · DEUniversity Hospital Ulm · DELudwig-Maximilians-Universität München · DEUniversity of Bonn · DEGerman Center for Neurodegenerative Diseases · DESaarland University · DEUniversität Hamburg · DEUniversitätsklinikum Würzburg · DEUniversity of Rostock · DEBG Klinikum Bergmannstrost Halle · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity Hospital Leipzig · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter,

Indexed as

AgedC9orf72 ProteinCerebellumFemaleFluorodeoxyglucose F18Frontotemporal Lobar DegenerationHumansMaleMiddle AgedMutationPositron-Emission TomographySensitivity and SpecificityThalamusC9orf72 ProteinC9orf72 protein, humanFluorodeoxyglucose F18

Identifiers

PMID30705258
PMCPMC6355852
OpenAlexW2911778678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.