ArticleTranslational psychiatry2019
Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations.PloS one · 2023Article
- Gene expression profiling in peripheral blood lymphocytes for major depression: preliminary cues from Chinese discordant sib-pair study.Translational psychiatry · 2021Article
- Article
- Factors Associated with Serious Psychological Distress during the COVID-19 Pandemic in Japan.medRxiv : the preprint server for health sciences · 2021Article
- The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder.International journal of bipolar disorders · 2020Article
- Psychiatric Genetics, Epigenetics, and Cellular Models in Coming Years.Journal of psychiatry and brain science · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is a common and disabling psychiatric disorder. A recent mega analysis of genome-wide association studies (GWASs) identified 44 loci associated with MDD, though most of the genetic etiologies of the MDD/psychological distress remain unclear. To further understand the genetic basis of MDD/psychological distress, we conducted a GWAS in East Asia with more than 10,000 participants of Japanese ancestry who had enrolled in a direct-to-consumer genetic test. After quality control on the genotype data, 10,330 subjects with a total of 8,567,708 imputed SNPs were eligible for the analysis. The participants completed a self-administered questionnaire on their past medical history and health conditions that included the 6-item Kessler screening scale (K6 scale) for psychological distress (cut-off point of 5) and past medical history of MDD, resulting in 3981 subjects assigned to "psychologically distressed group" [cases], and the remaining 6349 subjects were assigned to the "non-psychologically distressed group" [controls]. In this GWAS, we found an association with genome-wide significance at rs6073833 (P = 7.60 × 10
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