Evidence map›Paper›PMID 30705244›Full record

ArticleBMJ open2019

Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT).

Kathryn R Martin, Eva-Maria Bachmair, Lorna Aucott, Emma Dures, Richard Emsley, Stuart R Gray, Sarah Hewlett, Vinod Kumar, Karina Lovell, Gary J Macfarlane and 9 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03248518 nacompletednot on this map

Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: A Randomised Clinical Trial

TypeinterventionalSponsorUniversity of AberdeenRan2017 to 2020Enrolled368ConditionsRheumatoid Arthritis, Lupus Erythematosus, Systemic, Axial Spondyloarthritis, Psoriatic ArthritisArmsUsual Care, Cognitive behavioural approach, Personalised Exercise Programme
NCT06308770 narecruitingnot on this mapstarted 2024, after this paper: background citation

Fatigue in Lupus Intervention Programmes (FLIP): A Randomised Controlled Trial Investigating the Effectiveness of Fatigue Management in Systemic Lupus Erythematosus

TypeinterventionalSponsorUniversity of EdinburghRan2024 to 2027Enrolled90ConditionsSystemic Lupus ErythematosusArmsStandard Care, 4 week FMP, 7 week FMP
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 1 country.

Kathryn R Martin *Epidemiology Group, University of Aberdeen, Aberdeen, UK.
Eva-Maria Bachmair *Epidemiology Group, University of Aberdeen, Aberdeen, UK.
Lorna AucottCentre of Healthcare and Randomised Trials (CHaRT), Health Service Research Unit, University of Aberdeen, Aberdeen, UK.
Emma DuresDepartment of Nursing and Midwifery, University of the West of England, Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK.
Richard EmsleyDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Stuart R GrayInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Sarah HewlettDepartment of Nursing and Midwifery, University of the West of England, Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK.ORCID 0000-0001-7851-2039
Vinod KumarDepartment of Rheumatology, Ninewells Hospital, NHS Tayside, Dundee, UK.
Karina LovellSchool of Health Sciences, University of Manchester, Manchester, UK.
Gary J MacfarlaneEpidemiology Group, University of Aberdeen, Aberdeen, UK.
Graeme MacLennanCentre of Healthcare and Randomised Trials (CHaRT), Health Service Research Unit, University of Aberdeen, Aberdeen, UK.
Paul McNameeHealth Economics Research Unit, University of Aberdeen, Aberdeen, UK.
John NorrieEdinburgh Clinical Trials Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Lorna PaulSchool of Health and Life Science, Glasgow Caledonian University, Glasgow, UK.
Stuart RalstonRheumatology and Bone Disease, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Stefan SiebertInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Alison WeardenSchool of Health Sciences, University of Manchester, Manchester, UK.
Peter D WhiteDepartment of Psychological Medicine, Queen Mary University of London, Bartholomew's Hospital, London, UK.
Neil BasuInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
University of Aberdeen · GBUniversity of Glasgow · GBManchester Academic Health Science Centre · GBUniversity of the West of England · GBWestern General Hospital · GBGlasgow Caledonian University · GBKing's College London · GBNHS Tayside · GBSt Bartholomew's Hospital · GB

Funding

Chief Scientist Office HERU1Chief Scientist Office HSRU1Versus Arthritis 21175
6 · The paper itself

Abstract

introductionFatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable treatments which help patients with IRD to manage their fatigue. Yet, healthcare systems have encountered substantial barriers to the implementation of these therapeutic options. Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: a Randomised Trial (LIFT) is designed to give insights into the effectiveness of a remotely delivered standardised intervention for a range of patients with IRD. It will also enable the exploration of putative moderating factors which may allow for the future triage of patients and to investigate the precise mediators of treatment effect in IRD-related fatigue. METHODS AND ANALYSIS: LIFT is a pragmatic, multicentre, three-arm randomised, controlled trial, which will test whether adapted CBA and personalised exercise programme interventions can individually reduce the impact and severity of fatigue. This will be conducted with up to 375 eligible patients diagnosed with IRD and interventions will be delivered by rheumatology healthcare professionals, using the telephone or internet-based audio/video calls. ETHICS APPROVAL AND DISSEMINATION: Ethical approval has been granted by Wales REC 7 (17/WA/0065). Results of this study will be disseminated through presentation at scientific conferences and in scientific journal. A lay summary of the results will be sent to participants. TRIAL REGISTRATION NUMBER: NCT03248518; Pre-results.

Indexed as

Cognitive Behavioral TherapyCost-Benefit AnalysisExercise TherapyFatigueHumansMulticenter Studies as TopicPragmatic Clinical Trials as TopicQuality of LifeRandomized Controlled Trials as TopicRheumatic FeverSeverity of Illness Indexcognitive behaviouralexercisefatigueinflammatory rheumatic diseaseliftrandomised controlled trial

Identifiers

PMID30705244
PMCPMC6359876
OpenAlexW2913281612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.