ArticleScience (New York, N.Y.)2019
Opposing reactions in coenzyme A metabolism sensitize
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Acyl Carrier Protein is Essential for Apicoplast Biogenesis in Malaria Parasites Independent of Fatty Acid Synthesis.bioRxiv : the preprint server for biology · 2026Article
- Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase.Journal of medicinal chemistry · 2025Article
- Targeting Siderophore Biosynthesis to Thwart Microbial Growth.International journal of molecular sciences · 2025Review
- Manipulation and Structural Activity of AcpM inBiochemistry · 2025Article
- Exploring the compatibility of phosphopantetheinyl transferases with acyl carrier proteins spanning type II polyketide synthase sequence space.Journal of industrial microbiology & biotechnology · 2024Article
- Enzymatic Regulation of the Gut Microbiota: Mechanisms and Implications for Host Health.Biomolecules · 2024Review
- Redirecting raltitrexed from cancer cell thymidylate synthase toScience advances · 2024Article
- Metabolic Rewiring ofMetabolites · 2024Review
- Article
- Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation.Nature microbiology · 2023Article
- The human malaria parasiteProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A binuclear aluminium complex as a single competent catalyst for efficient synthesis of urea, biuret, isourea, isothiourea, phosphorylguanidine, and quinazolinones.RSC advances · 2023Article
- Using tea nanoclusters as β-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia: A promising therapeutic strategy by Chinese materioherbology.Fundamental research · 2022Article
- A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway ofACS infectious diseases · 2022Article
- In Vitro and In Vivo Inhibition of theJournal of medicinal chemistry · 2022Article
- Mycobacterial acyl carrier protein suppresses TFEB activation and upregulates miR-155 to inhibit host defense.Frontiers in immunology · 2022Article
- "Upcycling" known molecules and targets for drug-resistant TB.Frontiers in cellular and infection microbiology · 2022Article
- Advances in Key Drug Target Identification and New Drug Development for Tuberculosis.BioMed research international · 2022Review
- Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis.Microbiology spectrum · 2021Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
28 authors at 5 institutions in 2 countries.
Elaine BallingerDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-3879-2106
John MosiorDepartments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX, USA.ORCID 0000-0002-5649-7824
Travis HartmanDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-3926-6928
Kristin Burns-HuangDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
Ben GoldDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-9562-8241
Roxanne MorrisDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-7480-5424
Laurent GoullieuxInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
Isabelle BlancInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
Julien VaubourgeixDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-4872-0464
Sophie LagrangeInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
Laurent FraisseInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
Stéphanie SansInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.ORCID 0000-0003-3077-4536
Cedric CouturierInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.ORCID 0000-0002-1714-687X
Eric BacquéInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.ORCID 0000-0002-9339-5050
Kyu RheeDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
Sarah M ScarryDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-4261-2449
Jeffrey AubéDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-1049-5767
Guangbin YangOrganic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-3797-0054
Ouathek OuerfelliOrganic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7038-0219
Dirk SchnappingerDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-4445-7219
Thomas R IoergerDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-8702-9102
Curtis A EngelhartDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-9324-5861
Jennifer A McConnellDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-8549-5732
Kathrine McAulayDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-3817-9857
Allison FayImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5957-5376
Christine RoubertInfectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
James SacchettiniDepartments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX, USA. cnathan@med.cornell.edu sacchett@tamu.edu.ORCID 0000-0001-5767-2367
Carl NathanDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. cnathan@med.cornell.edu sacchett@tamu.edu.ORCID 0000-0002-7744-8896
Cornell University · USSanofi (France) · FRMemorial Sloan Kettering Cancer Center · USTexas College · USUniversity of North Carolina at Chapel Hill · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MViable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLICKMAN, MICHAEL S, NATHAN, CARL FRANCIS · 2014 to 2020
$48.6MVulnerabilities in Mycobacterial Cell-Wall BiogenesisP01AI095208 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SACCHETTINI, JAMES C · 2012 to 2022
$19.8MPREDOCTORAL TRAINING PROGRAM IN MICROBIAL PATHOGENESIST32AI007640 · NIAID · YALE UNIVERSITY · PI GOODMAN, ANDREW L · 2000 to 2022
$4.3MMedical Research Council MR/P028225/1NCI NIH HHS P30 CA008748NIAID NIH HHS P01 AI095208NIAID NIH HHS T32 AI007640NIAID NIH HHS U19 AI111143
Abstract
PubMed holds no abstract for this paper.
Indexed as
Acyl Carrier ProteinAnimalsBacterial ProteinsCatalytic DomainCoenzyme ADrug Resistance, BacterialFemaleGuanidineHydrolasesLipid MetabolismLoss of Function MutationMiceMice, Inbred BALB CMycobacterium tuberculosisOperonProtein BindingAcyl Carrier ProteinBacterial ProteinsCoenzyme AGuanidineguanidine carboxamideHydrolasesphosphopantetheinyl transferaseSmall Molecule LibrariesTransferases (Other Substituted Phosphate Groups)Urea
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.