Evidence map›Paper›PMID 30705154›Full record

ArticleScience (New York, N.Y.)2019

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.

Sebastian M Fica, Chris Oubridge, Max E Wilkinson, Andrew J Newman, Kiyoshi Nagai

Open access · bronzeAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 126 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Control of 3' splice site selection inRNA (New York, N.Y.) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Research Progress on the Relationship Between PRPF8 and Cancer.Current issues in molecular biology · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Control of 3' splice site selection by the yeast splicing factor Fyv6.bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sebastian M FicaMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. sfica@mrc-lmb.cam.ac.uk kn@mrc-lmb.cam.ac.uk.ORCID 0000-0001-9186-0361
Chris OubridgeMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0001-8492-8305
Max E WilkinsonMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0003-4738-9503
Andrew J NewmanMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0003-4077-4302
Kiyoshi NagaiMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. sfica@mrc-lmb.cam.ac.uk kn@mrc-lmb.cam.ac.uk.ORCID 0000-0003-1785-6510
MRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_U105184330
6 · The paper itself

Abstract

During exon ligation, the

Indexed as

Alternative SplicingExonsBiocatalysisCarrier ProteinsChromosomal Proteins, Non-HistoneCo-Repressor ProteinsCryoelectron MicroscopyDNA-Binding ProteinsHeLa CellsHumansNuclear ProteinsProtein ConformationRepressor ProteinsRNA PrecursorsRNA Splice SitesSpliceosomescactin protein, humanCarrier ProteinsChromosomal Proteins, Non-HistoneCo-Repressor ProteinsDNA-Binding ProteinsNKAP protein, humanNuclear ProteinsRepressor ProteinsRNA PrecursorsRNA Splice SitesSDE2 protein, humanSKA2 protein, human

Identifiers

PMID30705154
PMCPMC6386133
OpenAlexW2912940165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.