Evidence map›Paper›PMID 30705123›Full record

ArticleMolecular & cellular proteomics : MCP2019

Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome.

Lakmali Munasinghage Silva, Thomas Kryza, Thomas Stoll, Christine Hoogland, Ying Dong, Carson Ryan Stephens, Marcus Lachlan Hastie, Viktor Magdolen, Oded Kleifeld, Jeffrey John Gorman and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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  10. Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lakmali Munasinghage SilvaFrom the ‡Queensland University of Technology (QUT), Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences at the Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia;; ‖Klinische Forschergruppe der Frauenklinik, Klinikum Rechts der Isar, TU München, Munich, Germany. Electronic address: munasinghage.silva@nih.gov.
Thomas KryzaFrom the ‡Queensland University of Technology (QUT), Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences at the Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia;; ‖Klinische Forschergruppe der Frauenklinik, Klinikum Rechts der Isar, TU München, Munich, Germany.
Thomas Stoll§Protein Discovery Centre, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland, 4006, Australia.
Christine Hoogland§Protein Discovery Centre, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland, 4006, Australia;; ‖Klinische Forschergruppe der Frauenklinik, Klinikum Rechts der Isar, TU München, Munich, Germany.
Ying DongFrom the ‡Queensland University of Technology (QUT), Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences at the Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia.
Carson Ryan StephensFrom the ‡Queensland University of Technology (QUT), Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences at the Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia;; ‖Klinische Forschergruppe der Frauenklinik, Klinikum Rechts der Isar, TU München, Munich, Germany.
Marcus Lachlan Hastie§Protein Discovery Centre, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland, 4006, Australia.
Viktor Magdolen‖Klinische Forschergruppe der Frauenklinik, Klinikum Rechts der Isar, TU München, Munich, Germany.
Oded Kleifeld¶Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria, Australia 3800;; ‖Klinische Forschergruppe der Frauenklinik, Klinikum Rechts der Isar, TU München, Munich, Germany.
Jeffrey John Gorman§Protein Discovery Centre, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland, 4006, Australia.
Judith Ann ClementsFrom the ‡Queensland University of Technology (QUT), Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences at the Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia;. Electronic address: j.clements@qut.edu.au.
Klinikum rechts der Isar · DEQIMR Berghofer Medical Research Institute · AUQueensland University of Technology · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over expressed in ovarian cancer.

Indexed as

ProteolysisProteomicsAmino Acid SequenceCell Line, TumorChymotrypsinCulture Media, ConditionedEnzyme ActivationFemaleGene OntologyHumansHydrolysisKallikreinsMatrix Metalloproteinase 10Ovarian NeoplasmsPeptidesProteomeChymotrypsinCulture Media, ConditionedKallikreinsKLK7 protein, humanMatrix Metalloproteinase 10PeptidesProteomeThrombospondin 1Degradomics*Extracellular matrix*Kallikrein-related PeptidasesOvarian cancerProteases*SecretomeSubstrate identification

Identifiers

PMID30705123
PMCPMC6495248
OpenAlexW2915038743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.