ArticleOccupational and environmental medicine2019
Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark.
Article in Occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors of amyotrophic lateral sclerosis: a global meta-summary.Frontiers in neuroscience · 2023Pooled it
- Population-based study of environmental/occupational lead exposure and amyotrophic lateral sclerosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- Trace Elements Dyshomeostasis and Toxic Metals Neurotoxicity in Neurodegenerative Diseases.Biological trace element research · 2026Review
- The Effects of Lead, Cadmium and Arsenic Exposure Alone or in Combination on Neurotoxicity Through Neural Signaling Pathways.Biological trace element research · 2026Review
- Iron and Ferritin Dyshomeostasis Intersect with Sex, Age, and Disease Severity in Amyotrophic Lateral Sclerosis.Journal of molecular neuroscience : MN · 2025Article
- The Role of P62/Nrf2/Keap1 Signaling Pathway in Lead-Induced Neurological Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Occupational lead exposure and amyotrophic lateral sclerosis survival in the Danish National Patient Registry.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025Article
- Impact of lead exposure on global chronic kidney disease attributable to hypertension: deaths and disability-adjusted life years from 1990 to 2021 and projected trends for 2022-2036.Frontiers in public health · 2025Article
- Distributions and Trends of the Global Burden of DKD Attributable to Lead Exposure: A Systematic Analysis of GBD from 1990 to 2019.Biological trace element research · 2025Article
- Global, regional, and national burden of ischemic heart disease attributable to lead exposure, 1990-2021: decomposition, frontier, and projection analysis.Frontiers in public health · 2025Article
- Cognitive reserve in ALS: the role of occupational skills and requirements.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
- Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.Annals of neurology · 2024Review
- Chronic lead exposure and burden of cardiovascular disease during 1990-2019: a systematic analysis of the global burden of disease study.Frontiers in cardiovascular medicine · 2024Article
- Article
- Recognized cases of amyotrophic lateral sclerosis in automobile workers by the Korean Epidemiologic Investigation Evaluation Committee.Annals of occupational and environmental medicine · 2024Article
- The amyotrophic lateral sclerosis exposome: recent advances and future directions.Nature reviews. Neurology · 2023Review
- Bone lead variability in bone repository skeletal samples measured with portable x-ray fluorescence.The Science of the total environment · 2023Article
- Patterns of global burden of 13 diseases attributable to lead exposure, 1990-2019.BMC public health · 2023Article
- A Pilot Establishment of the Job-Exposure Matrix of Lead Using the Standard Process Code of Nationwide Exposure Databases in Korea.Safety and health at work · 2022Article
- Associations of self-reported occupational exposures and settings to ALS: a case-control study.International archives of occupational and environmental health · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesPrevious research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS.
methodsALS cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex.
resultsFor men with >50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher during any time 5 years prior to diagnosis (aOR: 1.35; 95% CI 1.04 to 1.76) and 10 years prior to diagnosis (aOR: 1.33; 95% CI 1.03 to 1.72). No significant associations were observed in women, and there were no linear trends seen for Pb exposures for either sex.
conclusionsOur study indicates an association between consistently higher occupational Pb exposures and ALS. These findings support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.
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